biostudies-literatureTerry KLNCI NIH HHS272-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC3076782biostudies-literatureUnknown1(4)Recent epidemiologic evidence supports a role for MUC1 in ovarian carcinogenesis; therefore, we hypothesized that common genetic variation in the genes responsible for glycosylation of MUC1 may influence ovarian cancer risk. In a genome-wide association study of ovarian cancer, we observed an association between a non-synonymous SNP (rs2271077) in the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosainyltransferase 2 (GALNT2) gene and ovarian cancer risk (p=0.005). We sought to validate the association in four population based ovarian cancer case-control studies collaborating through the Ovarian Cancer Association Consortium. Although rs2271077 was associated with a significantly increased risk (Odds Ratio (OR) = 1.37, 95% Confidence Interval (CI) = 1.06-1.77) in one study International journal of molecular epidemiology and geneticsA polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies.PMC3076782N01 CN025403R01 CA058598R01 CA054419Cramer DWTerry KLTitus-Ernstoff LGayther SAPharaoh PDSong HGoodman MTVitonis AFWilkens LRMenon ULurie GCarney MERamus SJGentry-Maharaj ABirrer MJHernandez DfalseA polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies.Recent epidemiologic evidence supports a role for MUC1 in ovarian carcinogenesis; therefore, we hypothesized that common genetic variation in the genes responsible for glycosylation of MUC1 may influence ovarian cancer risk. In a genome-wide association study of ovarian cancer, we observed an association between a non-synonymous SNP (rs2271077) in the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosainyltransferase 2 (GALNT2) gene and ovarian cancer risk (p=0.005). We sought to validate the association in four population based ovarian cancer case-control studies collaborating through the Ovarian Cancer Association Consortium. Although rs2271077 was associated with a significantly increased risk (Odds Ratio (OR) = 1.37, 95% Confidence Interval (CI) = 1.06-1.77) in one study 2010-01-01T00:00:00Z2010 Jul2025-04-21T19:13:30.97Z2019-03-27T00:40:40ZS-EPMC307678221532840