{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Elbaz A"],"funding":["NCRR NIH HHS","NIEHS NIH HHS","NINDS NIH HHS"],"pagination":["778-92"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3082599"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["69(5)"],"pubmed_abstract":["<h4>Objective</h4>We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium.<h4>Methods</h4>Participants of Caucasian ancestry were genotyped for a total of 4 SNCA (rs2583988, rs181489, rs356219, rs11931074) and 2 MAPT (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed- and random-effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case-control and case-only approach.<h"],"journal":["Annals of neurology"],"pubmed_title":["Independent and joint effects of the MAPT and SNCA genes in Parkinson disease."],"pmcid":["PMC3082599"],"funding_grant_id":["NS070276-01","R01 ES010751","RC2 NS070276","ES10758","P01 NS040256","P50NS40256","R01 NS057567","UL1 RR025752","R01 ES010758","2R01ES10751","P50 NS040256"],"pubmed_authors":["Dardiotis E","Vogiatzi C","Mellick GD","Legendre JP","Strongosky A","Riva C","Gasser T","Auburger G","Amouyel P","Searcy J","Chartier-Harlin MC","Wszolek ZK","Berg D","Tzourio C","Bordet R","Abahuni N","Kountra PM","Vilarino-Guell C","Tarantino P","Reimer J","Cobb SA","Bentivoglio AR","Aasly J","Siebert GA","Lynch T","Loriot MA","Sharma M","Farrer MJ","van de Loo S","Uitti RJ","Gibson JM","Valente EM","Bacon JA","Mutez E","Ferrarese C","Moisan F","Ferraris A","Nilsson K","Hadjigeorgiou GM","Stefanis L","Riess O","Geisen C","Silburn PA","Wirdefeldt K","Nilsson C","Pasquier F","Van Gerpen J","Maraganore DM","Annesi F","Annesi G","Pedersen NL","Ioannidis JP","Hilker R","Guidubaldi A","Mulot C","O'Sullivan JD","Stamboulis E","Lohmann K","Puschmann A","Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium","Ross OA","Boyle RS","Opala G","Dissanayaka N","Vassilatis D","Markou K","Caccialupi M","Lash J","Lambert JC","Patramani I","Xiromerisiou G","Klein C","Sutherland GT","Soto-Ortolaza AI","Brighina L","Destee A","Kruger R","Schulte C","Elbaz A","Jasinska-Myga B","De Nigris F","Bozi M","Quattrone A","Gispert S","Winkler S"],"additional_accession":[]},"is_claimable":false,"name":"Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.","description":"<h4>Objective</h4>We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium.<h4>Methods</h4>Participants of Caucasian ancestry were genotyped for a total of 4 SNCA (rs2583988, rs181489, rs356219, rs11931074) and 2 MAPT (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed- and random-effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case-control and case-only approach.<h","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 May","modification":"2026-05-03T18:51:31.183Z","creation":"2026-04-07T19:32:14.675Z"},"accession":"S-EPMC3082599","cross_references":{"pubmed":["21391235"],"doi":["10.1002/ana.22321"]}}