biostudies-literatureElbaz ANCRR NIH HHSNIEHS NIH HHSNINDS NIH HHS778-92https://www.ebi.ac.uk/biostudies/studies/S-EPMC3082599biostudies-literatureUnknown69(5)<h4>Objective</h4>We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium.<h4>Methods</h4>Participants of Caucasian ancestry were genotyped for a total of 4 SNCA (rs2583988, rs181489, rs356219, rs11931074) and 2 MAPT (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed- and random-effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case-control and case-only approach.<hAnnals of neurologyIndependent and joint effects of the MAPT and SNCA genes in Parkinson disease.PMC3082599NS070276-01R01 ES010751RC2 NS070276ES10758P01 NS040256P50NS40256R01 NS057567UL1 RR025752R01 ES0107582R01ES10751P50 NS040256Dardiotis EVogiatzi CMellick GDLegendre JPStrongosky ARiva CGasser TAuburger GAmouyel PSearcy JChartier-Harlin MCWszolek ZKBerg DTzourio CBordet RAbahuni NKountra PMVilarino-Guell CTarantino PReimer JCobb SABentivoglio ARAasly JSiebert GALynch TLoriot MASharma MFarrer MJvan de Loo SUitti RJGibson JMValente EMBacon JAMutez EFerrarese CMoisan FFerraris ANilsson KHadjigeorgiou GMStefanis LRiess OGeisen CSilburn PAWirdefeldt KNilsson CPasquier FVan Gerpen JMaraganore DMAnnesi FAnnesi GPedersen NLIoannidis JPHilker RGuidubaldi AMulot CO'Sullivan JDStamboulis ELohmann KPuschmann AGenetic Epidemiology of Parkinson's Disease (GEO-PD) ConsortiumRoss OABoyle RSOpala GDissanayaka NVassilatis DMarkou KCaccialupi MLash JLambert JCPatramani IXiromerisiou GKlein CSutherland GTSoto-Ortolaza AIBrighina LDestee AKruger RSchulte CElbaz AJasinska-Myga BDe Nigris FBozi MQuattrone AGispert SWinkler SfalseIndependent and joint effects of the MAPT and SNCA genes in Parkinson disease.<h4>Objective</h4>We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium.<h4>Methods</h4>Participants of Caucasian ancestry were genotyped for a total of 4 SNCA (rs2583988, rs181489, rs356219, rs11931074) and 2 MAPT (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed- and random-effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case-control and case-only approach.<h2011-01-01T00:00:00Z2011 May2026-05-03T18:51:31.183Z2026-04-07T19:32:14.675ZS-EPMC30825992139123510.1002/ana.22321