{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kishi Y"],"funding":["NCI NIH HHS"],"pagination":["6703-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3084064"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["108(17)"],"pubmed_abstract":["Buruli ulcer is a severe and devastating skin disease caused by Mycobacterium ulcerans infection, yet it is one of the most neglected diseases. The causative toxin, referred to as mycolactone A/B, was isolated and characterized as a polyketide-derived macrolide in 1999. The current status of the mycolactone chemistry is described, highlighting the stereochemistry assignment of mycolactone A/B; total synthesis; the structure determination of mycolactone congeners from the human pathogen M. ulcerans, the frog pathogen Mycobacterium liflandii, and the fish pathogen Mycobacterium marinum; the structural diversity in the mycolactone class of natural products; the highly sensitive detection/structure-analysis of mycolactones; and some biological activity."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Chemistry of mycolactones, the causative toxins of Buruli ulcer."],"pmcid":["PMC3084064"],"funding_grant_id":["CA 22215","R01 CA022215","R37 CA022215"],"pubmed_authors":["Kishi Y"],"additional_accession":[]},"is_claimable":false,"name":"Chemistry of mycolactones, the causative toxins of Buruli ulcer.","description":"Buruli ulcer is a severe and devastating skin disease caused by Mycobacterium ulcerans infection, yet it is one of the most neglected diseases. The causative toxin, referred to as mycolactone A/B, was isolated and characterized as a polyketide-derived macrolide in 1999. The current status of the mycolactone chemistry is described, highlighting the stereochemistry assignment of mycolactone A/B; total synthesis; the structure determination of mycolactone congeners from the human pathogen M. ulcerans, the frog pathogen Mycobacterium liflandii, and the fish pathogen Mycobacterium marinum; the structural diversity in the mycolactone class of natural products; the highly sensitive detection/structure-analysis of mycolactones; and some biological activity.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Apr","modification":"2026-07-01T03:09:59.882Z","creation":"2019-03-27T00:41:01Z"},"accession":"S-EPMC3084064","cross_references":{"pubmed":["21383136"],"doi":["10.1073/pnas.1015252108"]}}