biostudies-literatureKishi YNCI NIH HHS6703-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC3084064biostudies-literatureUnknown108(17)Buruli ulcer is a severe and devastating skin disease caused by Mycobacterium ulcerans infection, yet it is one of the most neglected diseases. The causative toxin, referred to as mycolactone A/B, was isolated and characterized as a polyketide-derived macrolide in 1999. The current status of the mycolactone chemistry is described, highlighting the stereochemistry assignment of mycolactone A/B; total synthesis; the structure determination of mycolactone congeners from the human pathogen M. ulcerans, the frog pathogen Mycobacterium liflandii, and the fish pathogen Mycobacterium marinum; the structural diversity in the mycolactone class of natural products; the highly sensitive detection/structure-analysis of mycolactones; and some biological activity.Proceedings of the National Academy of Sciences of the United States of AmericaChemistry of mycolactones, the causative toxins of Buruli ulcer.PMC3084064CA 22215R01 CA022215R37 CA022215Kishi YfalseChemistry of mycolactones, the causative toxins of Buruli ulcer.Buruli ulcer is a severe and devastating skin disease caused by Mycobacterium ulcerans infection, yet it is one of the most neglected diseases. The causative toxin, referred to as mycolactone A/B, was isolated and characterized as a polyketide-derived macrolide in 1999. The current status of the mycolactone chemistry is described, highlighting the stereochemistry assignment of mycolactone A/B; total synthesis; the structure determination of mycolactone congeners from the human pathogen M. ulcerans, the frog pathogen Mycobacterium liflandii, and the fish pathogen Mycobacterium marinum; the structural diversity in the mycolactone class of natural products; the highly sensitive detection/structure-analysis of mycolactones; and some biological activity.2011-01-01T00:00:00Z2011 Apr2026-07-01T03:09:59.882Z2019-03-27T00:41:01ZS-EPMC30840642138313610.1073/pnas.1015252108