biostudies-literatureAnderson CANCATS NIH HHSNIDDK NIH HHSNCRR NIH HHSNIAID NIH HHSNHLBI NIH HHSMedical Research CouncilChief Scientist OfficeWellcome TrustCrohn's and Colitis UK246-52https://www.ebi.ac.uk/biostudies/studies/S-EPMC3084597biostudies-literatureUnknown43(3)Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.Nature geneticsMeta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.PMC3084597U01 DK062431DK076984G0800759DK062413R01 AI062773G0800675U01 DK062432WT091745/Z/10/ZU01 DK062429P01-DK046763DK 063491N01HC75150U01 DK062420083948/Z/07/ZCZB/4/540WT089120/Z/09/ZDK064869UL1 TR000005U01 DK062423U01 DK062422R01 DK064869-08G0600329DK069513R01 DK064869-07M01 RR000425N01HC85079P30 DK063491U01 DK062432-10R01 DK083756G1002033AI062773M11-1DK83756U01 HL080295U01 DK062413R01 DK064869-05S1DK062431DK062432U01 DK062432-09U01 DK062432-07N01 HC035129U01 DK062432-08R21 DK084554P30 DK040561P01 DK046763M01-RR00425P30 DK043351R01 HL087652R01 DK060049R01 DK064869R01 DK064869-06A1N01 HC015103DK043351DK062429DK062423N01HC55222DK062420DK062422P30 DK040561-15DK084554K23 DK069513R03 DK076984Gazouli MGuthery SLMilla MWalters TTorkvist LSans MKugathasan SSatsangi JMathew CGSchreiber SAnderson CAZhao ZZDe Vos MSventoraityte JMcGovern DPDuerr RHGoyette PLevine AGlas JFehrmann RSAmininejad LKarlsen THWeersma RKRussell RFloyd JAPonsioen CYVatn MNewman WHalfvarson JFranke LDaly MJD'Amato MFranke APalmieri OWilson DCBaldassano RNLibioulle CEdwards CParkes MLatiano ALawrance IKupcinskas LLees CWVermeire SAnnese VTaylor KDFranchimont DLemann MChamaillard MLouis EHayward NKHugot JPXavier RJBayless TMTargan SRMowat CFlorin TBoucher GPapi LWijmenga CSimms LAPrescott NJRioux JDLee JCvan den Berg LHRotter JIRoberts RProctor DDAhmad TGeorges MAnagnou NPAndersen VBarclay MDenson LAMansfield JCSeibold FMorley KINg AGearry RJobin GSilverberg MSOphoff RABarrett JCSteinhart AHHakonarson HBrand SRadford-Smith GLaukens DSanderson JSharma YImielinski MDubinsky MHaritunians TColombel JFWestra HJPeyrin-Biroulet LVerspaget HCho JHScott RPhillips AGriffiths AMPanes JMontgomery GWLagace CBaidoo LEllinghaus DSchumm PBumpstead SRutgeerts PBrant SRSeielstad MGlazer NLBuning CfalseMeta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.2011-01-01T00:00:00Z2011 Mar2021-02-19T23:27:53Z2019-03-27T00:41:04ZS-EPMC30845972129763310.1038/ng.764