{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pinho S"],"funding":["NIMH NIH HHS","Medical Research Council","Biotechnology and Biological Sciences Research Council"],"pagination":["e19157"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3084772"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(4)"],"pubmed_abstract":["The amniote organizer (Hensen's node) can induce a complete nervous system when grafted into a peripheral region of a host embryo. Although BMP inhibition has been implicated in neural induction, non-neural cells cannot respond to BMP antagonists unless previously exposed to a node graft for at least 5 hours before BMP inhibitors. To define signals and responses during the first 5 hours of node signals, a differential screen was conducted. Here we describe three early response genes: two of them, Asterix and Obelix, encode previously undescribed proteins of unknown function but Obelix appears to be a nuclear RNA-binding protein. The third is TrkC, a neurotrophin receptor. All three genes are induced by a node graft within 4-5 hours but they differ in the extent to which they are inducible "],"journal":["PloS one"],"pubmed_title":["Distinct steps of neural induction revealed by Asterix, Obelix and TrkC, genes induced by different signals from the organizer."],"pmcid":["PMC3084772"],"funding_grant_id":["R01 MH060156","R01MH60156","G0400559","953782"],"pubmed_authors":["Sherlock WT","Sheng G","Pinho S","Khan M","Stower MJ","Stern CD","Simonsson PR","Streit A","Trevers KE"],"additional_accession":[]},"is_claimable":false,"name":"Distinct steps of neural induction revealed by Asterix, Obelix and TrkC, genes induced by different signals from the organizer.","description":"The amniote organizer (Hensen's node) can induce a complete nervous system when grafted into a peripheral region of a host embryo. Although BMP inhibition has been implicated in neural induction, non-neural cells cannot respond to BMP antagonists unless previously exposed to a node graft for at least 5 hours before BMP inhibitors. To define signals and responses during the first 5 hours of node signals, a differential screen was conducted. Here we describe three early response genes: two of them, Asterix and Obelix, encode previously undescribed proteins of unknown function but Obelix appears to be a nuclear RNA-binding protein. The third is TrkC, a neurotrophin receptor. All three genes are induced by a node graft within 4-5 hours but they differ in the extent to which they are inducible ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Apr","modification":"2025-04-18T18:50:49.483Z","creation":"2019-03-26T23:13:25Z"},"accession":"S-EPMC3084772","cross_references":{"pubmed":["21559472"],"doi":["10.1371/journal.pone.0019157"]}}