{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lai M"],"funding":["NCI NIH HHS","NINDS NIH HHS"],"pagination":["776-85"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3086669"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(8)"],"pubmed_abstract":["<h4>Background</h4>Voltage-gated potassium channels are thought to be the target of antibodies associated with limbic encephalitis. However, antibody testing using cells expressing voltage-gated potassium channels is negative; hence, we aimed to identify the real autoantigen associated with limbic encephalitis.<h4>Methods</h4>We analysed sera and CSF of 57 patients with limbic encephalitis and antibodies attributed to voltage-gated potassium channels and 148 control individuals who had other disorders with or without antibodies against voltage-gated potassium channels. Immunohistochemistry, immunoprecipitation, and mass spectrometry were used to characterise the antigen. An assay with HEK293 cells transfected with leucine-rich, glioma-inactivated 1 (LGI1) and disintegrin and metalloprotein"],"journal":["The Lancet. Neurology"],"pubmed_title":["Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series."],"pmcid":["PMC3086669"],"funding_grant_id":["RC1 NS068204","1RC1NS068204-01","R01 CA089054","R01 NS046706","R01 NS077851","R01 CA107192","R01 CA089054-02","R01CA107192","NS046706"],"pubmed_authors":["Huijbers MG","Cowell JK","Dalmau J","Lancaster E","Graus F","Bataller L","Lai M","Balice-Gordon R"],"additional_accession":[]},"is_claimable":false,"name":"Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series.","description":"<h4>Background</h4>Voltage-gated potassium channels are thought to be the target of antibodies associated with limbic encephalitis. However, antibody testing using cells expressing voltage-gated potassium channels is negative; hence, we aimed to identify the real autoantigen associated with limbic encephalitis.<h4>Methods</h4>We analysed sera and CSF of 57 patients with limbic encephalitis and antibodies attributed to voltage-gated potassium channels and 148 control individuals who had other disorders with or without antibodies against voltage-gated potassium channels. Immunohistochemistry, immunoprecipitation, and mass spectrometry were used to characterise the antigen. An assay with HEK293 cells transfected with leucine-rich, glioma-inactivated 1 (LGI1) and disintegrin and metalloprotein","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Aug","modification":"2025-04-18T18:56:55.192Z","creation":"2019-03-27T00:41:12Z"},"accession":"S-EPMC3086669","cross_references":{"pubmed":["20580615"],"doi":["10.1016/s1474-4422(10)70137-x","10.1016/S1474-4422(10)70137-X"]}}