{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Padinhateeri R"],"funding":["NCI NIH HHS"],"pagination":["7799-803"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3093463"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["108(19)"],"pubmed_abstract":["Accounting for enzyme-mediated active sliding, disassembly, and sequence-dependent positioning of nucleosomes, we simulate nucleosome occupancy over cell-cycle-scale times using a stochastic kinetic model. We show that ATP-dependent active nucleosome sliding and nucleosome removal processes are essential to obtain in vivo-like nucleosome positioning. While active sliding leads to dense nucleosome filling, sliding events alone cannot ensure sequence-dependent nucleosome positioning: Active nucleosome removal is the crucial remodeling event that drives positioning. We also show that remodeling activity changes nucleosome dynamics from glassy to liquid-like, and that remodeling dramatically influences exposure dynamics of promoter regions."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Nucleosome positioning in a model of active chromatin remodeling enzymes."],"pmcid":["PMC3093463"],"funding_grant_id":["U54 CA143869","U54-CA143869-01"],"pubmed_authors":["Padinhateeri R","Marko JF"],"additional_accession":[]},"is_claimable":false,"name":"Nucleosome positioning in a model of active chromatin remodeling enzymes.","description":"Accounting for enzyme-mediated active sliding, disassembly, and sequence-dependent positioning of nucleosomes, we simulate nucleosome occupancy over cell-cycle-scale times using a stochastic kinetic model. We show that ATP-dependent active nucleosome sliding and nucleosome removal processes are essential to obtain in vivo-like nucleosome positioning. While active sliding leads to dense nucleosome filling, sliding events alone cannot ensure sequence-dependent nucleosome positioning: Active nucleosome removal is the crucial remodeling event that drives positioning. We also show that remodeling activity changes nucleosome dynamics from glassy to liquid-like, and that remodeling dramatically influences exposure dynamics of promoter regions.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 May","modification":"2025-04-04T07:35:48.439Z","creation":"2019-03-27T00:41:33Z"},"accession":"S-EPMC3093463","cross_references":{"pubmed":["21518900"],"doi":["10.1073/pnas.1015206108"]}}