{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pejchal R"],"funding":["NIAID NIH HHS"],"pagination":["3744-53"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3096478"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(33)"],"pubmed_abstract":["Traditional vaccine approaches have failed for HIV and novel strategies are now being sought to develop immunogens designed to elicit specific activity against known broad neutralization epitopes. Structure-based vaccine design has great potential but, thus far, remains a largely unproven concept. Further structural information for the envelope (Env) glycoproteins, gp120 and gp41, is needed, particularly for understanding trimer-specific antibodies and their epitopes and to clarify atomic details of the structural elements responsible for masking crucial epitopes and for mediating the conformational rearrangements undertaken during the process of receptor-binding and membrane fusion."],"journal":["Current pharmaceutical design"],"pubmed_title":["Structure-based vaccine design in HIV: blind men and the elephant?"],"pmcid":["PMC3096478"],"funding_grant_id":["F32 AI074372","R56 AI084817","R01 AI084817-03","F32 AI074372-03","R01 AI084817","AI84817","AI74372"],"pubmed_authors":["Pejchal R","Wilson IA"],"additional_accession":[]},"is_claimable":false,"name":"Structure-based vaccine design in HIV: blind men and the elephant?","description":"Traditional vaccine approaches have failed for HIV and novel strategies are now being sought to develop immunogens designed to elicit specific activity against known broad neutralization epitopes. Structure-based vaccine design has great potential but, thus far, remains a largely unproven concept. Further structural information for the envelope (Env) glycoproteins, gp120 and gp41, is needed, particularly for understanding trimer-specific antibodies and their epitopes and to clarify atomic details of the structural elements responsible for masking crucial epitopes and for mediating the conformational rearrangements undertaken during the process of receptor-binding and membrane fusion.","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010","modification":"2021-02-19T21:43:21Z","creation":"2019-03-27T00:41:40Z"},"accession":"S-EPMC3096478","cross_references":{"pubmed":["21128885"],"doi":["10.2174/138161210794079173"]}}