biostudies-literatureUnknown12(5)Nesaretnam K<h4>Introduction</h4>Basic research has indicated that tocotrienols have potent antiproliferative and proapoptotic effects that would be expected to reduce the effect of breast cancer.<h4>Methods</h4>We conducted a double-blinded, placebo-controlled pilot trial to test the effectiveness of adjuvant tocotrienol therapy in combination with tamoxifen for five years in women with early breast cancer. Two-hundred-forty women, aged between 40-60 years, with either tumor node metastases (TNM) Stage I or II breast cancer and estrogen receptor (ER) positive tumors were non-randomly assigned to two groups. The intervention group received tocotrienol rich fraction (TRF) plus tamoxifen whilst the control group received placebo plus tamoxifen, for five years.<h4>Results</h4>During the five years of stuBreast cancer research : BCRR81https://www.ebi.ac.uk/biostudies/studies/S-EPMC3096974biostudies-literatureEffectiveness of tocotrienol-rich fraction combined with tamoxifen in the management of women with early breast cancer: a pilot clinical trial.PMC3096974Nesaretnam KSelvaduray KRGomez PAAbdul Razak GVeerasenan SDfalseEffectiveness of tocotrienol-rich fraction combined with tamoxifen in the management of women with early breast cancer: a pilot clinical trial.<h4>Introduction</h4>Basic research has indicated that tocotrienols have potent antiproliferative and proapoptotic effects that would be expected to reduce the effect of breast cancer.<h4>Methods</h4>We conducted a double-blinded, placebo-controlled pilot trial to test the effectiveness of adjuvant tocotrienol therapy in combination with tamoxifen for five years in women with early breast cancer. Two-hundred-forty women, aged between 40-60 years, with either tumor node metastases (TNM) Stage I or II breast cancer and estrogen receptor (ER) positive tumors were non-randomly assigned to two groups. The intervention group received tocotrienol rich fraction (TRF) plus tamoxifen whilst the control group received placebo plus tamoxifen, for five years.<h4>Results</h4>During the five years of stu2010-01-01T00:00:00Z20102025-04-18T23:31:43.13Z2019-03-27T00:41:42ZS-EPMC30969742092959210.1186/bcr2726