{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(5)"],"submitter":["Shatnyeva OM"],"pubmed_abstract":["Protein modifications of death receptor pathways play a central role in the regulation of apoptosis. It has been demonstrated that O-glycosylation of TRAIL-receptor (R) is essential for sensitivity and resistance towards TRAIL-mediated apoptosis. In this study we ask whether and how glycosylation of CD95 (Fas/APO-1), another death receptor, influences DISC formation and procaspase-8 activation at the CD95 DISC and thereby the onset of apoptosis. We concentrated on N-glycostructure since O-glycosylation of CD95 was not found. We applied different approaches to analyze the role of CD95 N-glycosylation on the signal transduction: in silico modeling of CD95 DISC, generation of CD95 glycosylation mutants (at N136 and N118), modulation of N-glycosylation by deoxymannojirimycin (DMM) and sialidas"],"journal":["PloS one"],"pagination":["e19927"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3097226"],"repository":["biostudies-literature"],"pubmed_title":["Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation."],"pmcid":["PMC3097226"],"pubmed_authors":["Schwartz-Albiez R","Lavrik IN","Pappa A","Weber AN","Weber CE","Krammer PH","Kubarenko AV","Shatnyeva OM"],"additional_accession":[]},"is_claimable":false,"name":"Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation.","description":"Protein modifications of death receptor pathways play a central role in the regulation of apoptosis. It has been demonstrated that O-glycosylation of TRAIL-receptor (R) is essential for sensitivity and resistance towards TRAIL-mediated apoptosis. In this study we ask whether and how glycosylation of CD95 (Fas/APO-1), another death receptor, influences DISC formation and procaspase-8 activation at the CD95 DISC and thereby the onset of apoptosis. We concentrated on N-glycostructure since O-glycosylation of CD95 was not found. We applied different approaches to analyze the role of CD95 N-glycosylation on the signal transduction: in silico modeling of CD95 DISC, generation of CD95 glycosylation mutants (at N136 and N118), modulation of N-glycosylation by deoxymannojirimycin (DMM) and sialidas","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011","modification":"2026-04-07T14:27:33.382Z","creation":"2019-03-26T23:13:27Z"},"accession":"S-EPMC3097226","cross_references":{"pubmed":["21625644"],"doi":["10.1371/journal.pone.0019927"]}}