{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Yeh CY"],"pubmed_abstract":["<h4>Background</h4>A cross-talk between different receptor tyrosine kinases (RTKs) plays an important role in the pathogenesis of human cancers.<h4>Methods</h4>Both NIH-Met5 and T24-Met3 cell lines harboring an inducible human c-Met gene were established. C-Met-related RTKs were screened by RTK microarray analysis. The cross-talk of RTKs was demonstrated by Western blotting and confirmed by small interfering RNA (siRNA) silencing, followed by elucidation of the underlying mechanism. The impact of this cross-talk on biological function was demonstrated by Trans-well migration assay. Finally, the potential clinical importance was examined in a cohort of 65 cases of locally advanced and metastatic bladder cancer patients.<h4>Results</h4>A positive association of Axl or platelet-derived growth"],"journal":["BMC cancer"],"pagination":["139"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3101176"],"repository":["biostudies-literature"],"pubmed_title":["Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer."],"pmcid":["PMC3101176"],"pubmed_authors":["Chow NH","Yeh CY","Shin JW","Wu TJ","Lee CT","Chang TY","Lee YC","Raghavaraju G","Shin SM","Tseng VS","Shen CH","Yeh HH","Chiang JH","Liu HS"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer.","description":"<h4>Background</h4>A cross-talk between different receptor tyrosine kinases (RTKs) plays an important role in the pathogenesis of human cancers.<h4>Methods</h4>Both NIH-Met5 and T24-Met3 cell lines harboring an inducible human c-Met gene were established. C-Met-related RTKs were screened by RTK microarray analysis. The cross-talk of RTKs was demonstrated by Western blotting and confirmed by small interfering RNA (siRNA) silencing, followed by elucidation of the underlying mechanism. The impact of this cross-talk on biological function was demonstrated by Trans-well migration assay. Finally, the potential clinical importance was examined in a cohort of 65 cases of locally advanced and metastatic bladder cancer patients.<h4>Results</h4>A positive association of Axl or platelet-derived growth","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Apr","modification":"2026-04-07T14:00:22.153Z","creation":"2026-04-07T13:42:40.43Z"},"accession":"S-EPMC3101176","cross_references":{"pubmed":["21496277"],"doi":["10.1186/1471-2407-11-139"]}}