biostudies-literatureUnknown11Yeh CY<h4>Background</h4>A cross-talk between different receptor tyrosine kinases (RTKs) plays an important role in the pathogenesis of human cancers.<h4>Methods</h4>Both NIH-Met5 and T24-Met3 cell lines harboring an inducible human c-Met gene were established. C-Met-related RTKs were screened by RTK microarray analysis. The cross-talk of RTKs was demonstrated by Western blotting and confirmed by small interfering RNA (siRNA) silencing, followed by elucidation of the underlying mechanism. The impact of this cross-talk on biological function was demonstrated by Trans-well migration assay. Finally, the potential clinical importance was examined in a cohort of 65 cases of locally advanced and metastatic bladder cancer patients.<h4>Results</h4>A positive association of Axl or platelet-derived growthBMC cancer139https://www.ebi.ac.uk/biostudies/studies/S-EPMC3101176biostudies-literatureTranscriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer.PMC3101176Chow NHYeh CYShin JWWu TJLee CTChang TYLee YCRaghavaraju GShin SMTseng VSShen CHYeh HHChiang JHLiu HSfalseTranscriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer.<h4>Background</h4>A cross-talk between different receptor tyrosine kinases (RTKs) plays an important role in the pathogenesis of human cancers.<h4>Methods</h4>Both NIH-Met5 and T24-Met3 cell lines harboring an inducible human c-Met gene were established. C-Met-related RTKs were screened by RTK microarray analysis. The cross-talk of RTKs was demonstrated by Western blotting and confirmed by small interfering RNA (siRNA) silencing, followed by elucidation of the underlying mechanism. The impact of this cross-talk on biological function was demonstrated by Trans-well migration assay. Finally, the potential clinical importance was examined in a cohort of 65 cases of locally advanced and metastatic bladder cancer patients.<h4>Results</h4>A positive association of Axl or platelet-derived growth2011-01-01T00:00:00Z2011 Apr2026-04-07T14:00:22.153Z2026-04-07T13:42:40.43ZS-EPMC31011762149627710.1186/1471-2407-11-139