biostudies-literatureBiggins JBHoward Hughes Medical InstituteNIAID NIH HHSNIGMS NIH HHS1536-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC3103185biostudies-literatureUnknown13(6)Natural product gene clusters are often tightly regulated, resulting in gene cluster silencing in laboratory fermentation studies. The systematic overexpression of transcription factors (TFs) associated with biosynthetic gene clusters found in the genome of Burkholderia thailandensis E264 identified a set of TFs that, when overexpressed, alter the secondary metabolome of this bacterium. The isolation and characterization of burkholdacs A and B, two new acyldepsitripeptide histone deacetylase inhibitors produced by B. thailandensis overexpressing the TF bhcM, is reported.Organic lettersAcyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis.PMC3103185R01 GM077516-04U54-AI057158U54 AI057158GM077516R01 GM077516U54 AI057158-04Biggins JBGleber CDBrady SFfalseAcyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis.Natural product gene clusters are often tightly regulated, resulting in gene cluster silencing in laboratory fermentation studies. The systematic overexpression of transcription factors (TFs) associated with biosynthetic gene clusters found in the genome of Burkholderia thailandensis E264 identified a set of TFs that, when overexpressed, alter the secondary metabolome of this bacterium. The isolation and characterization of burkholdacs A and B, two new acyldepsitripeptide histone deacetylase inhibitors produced by B. thailandensis overexpressing the TF bhcM, is reported.2011-01-01T00:00:00Z2011 Mar2025-04-04T00:16:12.12Z2019-03-27T00:42:03ZS-EPMC31031852134845410.1021/ol200225v