{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dougan M"],"funding":["NIA NIH HHS","NCI NIH HHS"],"pagination":["2436-46"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3104747"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(6)"],"pubmed_abstract":["Lung cancer is the leading cause of cancer death worldwide. Both principal factors known to cause lung cancer, cigarette smoke and asbestos, induce pulmonary inflammation, and pulmonary inflammation has recently been implicated in several murine models of lung cancer. To further investigate the role of inflammation in the development of lung cancer, we generated mice with combined loss of IFN-γ and the β-common cytokines GM-CSF and IL-3. These immunodeficient mice develop chronic pulmonary inflammation and lung tumors at a high frequency. Examination of the relationship between these tumors and their inflammatory microenvironment revealed a dual role for the immune system in tumor development. The inflammatory cytokine IL-6 promoted optimal tumor growth, yet wild-type mice rejected transpl"],"journal":["The Journal of clinical investigation"],"pubmed_title":["A dual role for the immune response in a mouse model of inflammation-associated lung cancer."],"pmcid":["PMC3104747"],"funding_grant_id":["R01 CA122794","P01 CA155258","R01 CA140594","P50 CA100707","R01 CA143083","F30 AG030298","F30AG030298","R01 CA050947","P01 CA078378"],"pubmed_authors":["Neuberg D","Mihm M","Dougan M","Li D","Googe P","Wong KK","Dranoff G"],"additional_accession":[]},"is_claimable":false,"name":"A dual role for the immune response in a mouse model of inflammation-associated lung cancer.","description":"Lung cancer is the leading cause of cancer death worldwide. Both principal factors known to cause lung cancer, cigarette smoke and asbestos, induce pulmonary inflammation, and pulmonary inflammation has recently been implicated in several murine models of lung cancer. To further investigate the role of inflammation in the development of lung cancer, we generated mice with combined loss of IFN-γ and the β-common cytokines GM-CSF and IL-3. These immunodeficient mice develop chronic pulmonary inflammation and lung tumors at a high frequency. Examination of the relationship between these tumors and their inflammatory microenvironment revealed a dual role for the immune system in tumor development. The inflammatory cytokine IL-6 promoted optimal tumor growth, yet wild-type mice rejected transpl","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jun","modification":"2026-05-01T13:55:31.935Z","creation":"2019-03-27T00:42:08Z"},"accession":"S-EPMC3104747","cross_references":{"pubmed":["21537082"],"doi":["10.1172/JCI44796","10.1172/jci44796"]}}