biostudies-literatureSmajs DNIDCR NIH HHSNEI NIH HHSNIDA NIH HHSNIAID NIH HHSNHGRI NIH HHSe20415https://www.ebi.ac.uk/biostudies/studies/S-EPMC3105029biostudies-literatureUnknown6(5)Treponema paraluiscuniculi is the causative agent of rabbit venereal spirochetosis. It is not infectious to humans, although its genome structure is very closely related to other pathogenic Treponema species including Treponema pallidum subspecies pallidum, the etiological agent of syphilis. In this study, the genome sequence of Treponema paraluiscuniculi, strain Cuniculi A, was determined by a combination of several high-throughput sequencing strategies. Whereas the overall size (1,133,390 bp), arrangement, and gene content of the Cuniculi A genome closely resembled those of the T. pallidum genome, the T. paraluiscuniculi genome contained a markedly higher number of pseudogenes and gene fragments (51). In addition to pseudogenes, 33 divergent genes were also found in the T. paraluiscunicuPloS oneComplete genome sequence of Treponema paraluiscuniculi, strain Cuniculi A: the loss of infectivity to humans is associated with genome decay.PMC3105029R01 DE12488R01 AI49252R01 AI049252U54 HG003273R01 EY013759R03 AI69107R01 DA013759R01 DE13759R03 AI069107Muzny DMCejkova DHallsworth-Pepin KChen LQin XGibbs RAZobanikova MAlbert TNorris SJWeinstock GMStrouhal MDugan-Rocha SBuhay CSmajs DPospisilova PfalseComplete genome sequence of Treponema paraluiscuniculi, strain Cuniculi A: the loss of infectivity to humans is associated with genome decay.Treponema paraluiscuniculi is the causative agent of rabbit venereal spirochetosis. It is not infectious to humans, although its genome structure is very closely related to other pathogenic Treponema species including Treponema pallidum subspecies pallidum, the etiological agent of syphilis. In this study, the genome sequence of Treponema paraluiscuniculi, strain Cuniculi A, was determined by a combination of several high-throughput sequencing strategies. Whereas the overall size (1,133,390 bp), arrangement, and gene content of the Cuniculi A genome closely resembled those of the T. pallidum genome, the T. paraluiscuniculi genome contained a markedly higher number of pseudogenes and gene fragments (51). In addition to pseudogenes, 33 divergent genes were also found in the T. paraluiscunicu2011-01-01T00:00:00Z20112026-05-05T00:08:51.998Z2026-04-07T21:09:10.934ZS-EPMC31050292165524410.1371/journal.pone.0020415