{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(5)"],"submitter":["Xu L"],"pubmed_abstract":["<h4>Background</h4>CD4(+)CD25(+) regulatory T cells (Tregs), a heterogeneous population, were enrichment in tumor mass and played an important role in modulating anti-tumor immunity. Recently, we reported a Treg subset, CCR6(+) Tregs but not CCR6(-)Tregs, were enriched in tumor mass and closely related to poor prognosis of breast cancer patients. However, the underlying mechanism remains elusive. Here, we carefully evaluate the enrichment of CCR6(+)Tregs in tumor mass during progression of breast cancer and explore its possible mechanism.<h4>Methodology/principal findings</h4>The frequency of CCR6(+)Tregs in tumor infiltrating lymphocytes (TILs ) was analyzed at early stage and at late stage of tumor in a murine breast cancer model by FACS respectively. The expansion of CCR6(+)Tregs and th"],"journal":["PloS one"],"pagination":["e20282"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3105045"],"repository":["biostudies-literature"],"pubmed_title":["In situ prior proliferation of CD4+ CCR6+ regulatory T cells facilitated by TGF-β secreting DCs is crucial for their enrichment and suppression in tumor immunity."],"pmcid":["PMC3105045"],"pubmed_authors":["Xu L","Wen Z","Xiong S","Xu W"],"additional_accession":[]},"is_claimable":false,"name":"In situ prior proliferation of CD4+ CCR6+ regulatory T cells facilitated by TGF-β secreting DCs is crucial for their enrichment and suppression in tumor immunity.","description":"<h4>Background</h4>CD4(+)CD25(+) regulatory T cells (Tregs), a heterogeneous population, were enrichment in tumor mass and played an important role in modulating anti-tumor immunity. Recently, we reported a Treg subset, CCR6(+) Tregs but not CCR6(-)Tregs, were enriched in tumor mass and closely related to poor prognosis of breast cancer patients. However, the underlying mechanism remains elusive. Here, we carefully evaluate the enrichment of CCR6(+)Tregs in tumor mass during progression of breast cancer and explore its possible mechanism.<h4>Methodology/principal findings</h4>The frequency of CCR6(+)Tregs in tumor infiltrating lymphocytes (TILs ) was analyzed at early stage and at late stage of tumor in a murine breast cancer model by FACS respectively. The expansion of CCR6(+)Tregs and th","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011","modification":"2025-07-08T03:12:45.243Z","creation":"2025-07-08T03:12:45.243Z"},"accession":"S-EPMC3105045","cross_references":{"pubmed":["21655250"],"doi":["10.1371/journal.pone.0020282"]}}