{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["113(2)"],"submitter":["Sokolow S"],"pubmed_abstract":["We produced and analyzed mice deficient for Na/Ca exchanger 3 (NCX3), a protein that mediates cellular Ca(2+) efflux (forward mode) or Ca(2+) influx (reverse mode) and thus controls intracellular Ca(2+) concentration. NCX3-deficient mice (Ncx3(-/-)) present a skeletal muscle fiber necrosis and a defective neuromuscular transmission, reflecting the absence of NCX3 in the sarcolemma of the muscle fibers and at the neuromuscular junction. The defective neuromuscular transmission is characterized by the presence of electromyographic abnormalities, including low compound muscle action potential amplitude, a decremental response at low-frequency nerve stimulation, an incremental response, and a prominent postexercise facilitation at high-frequency nerve stimulation, as well as neuromuscular bloc"],"journal":["The Journal of clinical investigation"],"pagination":["265-73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC310749"],"repository":["biostudies-literature"],"pubmed_title":["Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3."],"pmcid":["PMC310749"],"pubmed_authors":["Molgo J","Herchuelz A","Schurmans S","Manto M","Sokolow S","Vanderwinden JM","Gailly P","Vandebrouck C"],"additional_accession":[]},"is_claimable":false,"name":"Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3.","description":"We produced and analyzed mice deficient for Na/Ca exchanger 3 (NCX3), a protein that mediates cellular Ca(2+) efflux (forward mode) or Ca(2+) influx (reverse mode) and thus controls intracellular Ca(2+) concentration. NCX3-deficient mice (Ncx3(-/-)) present a skeletal muscle fiber necrosis and a defective neuromuscular transmission, reflecting the absence of NCX3 in the sarcolemma of the muscle fibers and at the neuromuscular junction. The defective neuromuscular transmission is characterized by the presence of electromyographic abnormalities, including low compound muscle action potential amplitude, a decremental response at low-frequency nerve stimulation, an incremental response, and a prominent postexercise facilitation at high-frequency nerve stimulation, as well as neuromuscular bloc","dates":{"release":"2004-01-01T00:00:00Z","publication":"2004 Jan","modification":"2025-04-03T22:54:48.319Z","creation":"2019-03-27T00:49:55Z"},"accession":"S-EPMC310749","cross_references":{"pubmed":["14722618"],"doi":["10.1172/JCI18688","10.1172/jci200418688"]}}