{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Serre K"],"funding":["Medical Research Council","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["e20731"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3108993"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(6)"],"pubmed_abstract":["<h4>Background</h4>Although in vitro IL-4 directs CD4 T cells to produce T helper 2 (Th2)-cytokines, these cytokines can be induced in vivo in the absence of IL-4-signalling. Thus, mechanism(s), different from the in vitro pathway for Th2-induction, contribute to in vivo Th2-differentiation. The pathway for in vivo IL-4-independent Th2-differentiation has yet to be characterized.<h4>Findings</h4>Helios (ikzf2), a member of the Ikaros transcription regulator family, is expressed in thymocytes and some antigen-matured T cells as well as in regulatory T cells. It has been proposed that Helios is a specific marker for thymus-derived regulatory T cells. Here, we show that mouse ovalbumin-specific CD4 (OTII) cells responding to alum-precipitated ovalbumin (alumOVA) upregulate Th2 features - GATA"],"journal":["PloS one"],"pubmed_title":["Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression."],"pmcid":["PMC3108993"],"funding_grant_id":["G8402371","G9818340","G9818340B","G0701275","BB/F022778/1"],"pubmed_authors":["Desanti G","Bobat S","Mohr E","Serre K","Cunningham AF","Bird R","Toellner KM","Maclennan IC","Chan S","Kastner P","Benezech C"],"additional_accession":[]},"is_claimable":false,"name":"Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.","description":"<h4>Background</h4>Although in vitro IL-4 directs CD4 T cells to produce T helper 2 (Th2)-cytokines, these cytokines can be induced in vivo in the absence of IL-4-signalling. Thus, mechanism(s), different from the in vitro pathway for Th2-induction, contribute to in vivo Th2-differentiation. The pathway for in vivo IL-4-independent Th2-differentiation has yet to be characterized.<h4>Findings</h4>Helios (ikzf2), a member of the Ikaros transcription regulator family, is expressed in thymocytes and some antigen-matured T cells as well as in regulatory T cells. It has been proposed that Helios is a specific marker for thymus-derived regulatory T cells. Here, we show that mouse ovalbumin-specific CD4 (OTII) cells responding to alum-precipitated ovalbumin (alumOVA) upregulate Th2 features - GATA","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011","modification":"2026-04-14T13:36:50.811Z","creation":"2025-05-18T11:23:32.848Z"},"accession":"S-EPMC3108993","cross_references":{"pubmed":["21677778"],"doi":["10.1371/journal.pone.0020731"]}}