{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang D"],"funding":["NIGMS NIH HHS"],"pagination":["2144-2147"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3110011"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(17)"],"pubmed_abstract":["Regioselective titanium alkoxide-mediated reductive cross-coupling reactions of allylic alcohols with vinylsilanes and imines have previously been demonstrated to proceed with allylic transposition by formal metallo-[3,3]-rearrangement [thought to proceed by a sequence of: 1) directed carbometalation, and 2) syn-elimination]. While many examples have been described that support this reaction path, a collection of substrates have recently been identified that react by way of an alternative pathway, delivering a concise convergent route to coupled products bearing a quaternary center."],"journal":["Tetrahedron letters"],"pubmed_title":["Generation of quaternary centers by reductive cross-coupling: shifting of regioselectivity in a subset of allylic alcohol-based coupling reactions."],"pmcid":["PMC3110011"],"funding_grant_id":["R01 GM080266","R01 GM080266-05"],"pubmed_authors":["Micalizio GC","Belardi JK","Yang D"],"additional_accession":[]},"is_claimable":false,"name":"Generation of quaternary centers by reductive cross-coupling: shifting of regioselectivity in a subset of allylic alcohol-based coupling reactions.","description":"Regioselective titanium alkoxide-mediated reductive cross-coupling reactions of allylic alcohols with vinylsilanes and imines have previously been demonstrated to proceed with allylic transposition by formal metallo-[3,3]-rearrangement [thought to proceed by a sequence of: 1) directed carbometalation, and 2) syn-elimination]. While many examples have been described that support this reaction path, a collection of substrates have recently been identified that react by way of an alternative pathway, delivering a concise convergent route to coupled products bearing a quaternary center.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Apr","modification":"2024-10-18T00:58:47.597Z","creation":"2019-03-27T00:42:21Z"},"accession":"S-EPMC3110011","cross_references":{"pubmed":["21666832"],"doi":["10.1016/j.tetlet.2010.11.059"]}}