{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["286(24)"],"submitter":["von Rossum A"],"funding":["Canadian Institutes of Health Research"],"pubmed_abstract":["The nature of inflammatory signals determines the outcome of T cell responses. However, little is known about how inflammatory cytokines provided to human CD8 T cells during activation affects their susceptibility to post-activation cell death. We have examined and compared the effects of the inflammatory cytokine IL-12, as well as the combination of IL-1, IL-6, and IL-23 (IL-1/6/23) on the susceptibility of primary human CD8 T cells to post-activation cell death. Human CD8 T cells activated in the presence of IL-1/6/23 underwent significantly less cell death after activation as compared with those activated in IL-12. This was due to reduced susceptibility to Fas-mediated activation-induced cell death (AICD). Mechanistically, the reduced level of cell death in CD8 T cells activated in IL-1"],"journal":["The Journal of biological chemistry"],"pagination":["21137-44"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3122175"],"repository":["biostudies-literature"],"pubmed_title":["Inflammatory cytokines determine the susceptibility of human CD8 T cells to Fas-mediated activation-induced cell death through modulation of FasL and c-FLIP(S) expression."],"pmcid":["PMC3122175"],"pubmed_authors":["von Rossum A","Choy JC","Krall R","Escalante NK"],"additional_accession":[]},"is_claimable":false,"name":"Inflammatory cytokines determine the susceptibility of human CD8 T cells to Fas-mediated activation-induced cell death through modulation of FasL and c-FLIP(S) expression.","description":"The nature of inflammatory signals determines the outcome of T cell responses. However, little is known about how inflammatory cytokines provided to human CD8 T cells during activation affects their susceptibility to post-activation cell death. We have examined and compared the effects of the inflammatory cytokine IL-12, as well as the combination of IL-1, IL-6, and IL-23 (IL-1/6/23) on the susceptibility of primary human CD8 T cells to post-activation cell death. Human CD8 T cells activated in the presence of IL-1/6/23 underwent significantly less cell death after activation as compared with those activated in IL-12. This was due to reduced susceptibility to Fas-mediated activation-induced cell death (AICD). Mechanistically, the reduced level of cell death in CD8 T cells activated in IL-1","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jun","modification":"2025-04-04T21:57:18.86Z","creation":"2019-03-27T00:42:57Z"},"accession":"S-EPMC3122175","cross_references":{"pubmed":["21518761"],"doi":["10.1074/jbc.m110.197657","10.1074/jbc.M110.197657"]}}