{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Overton IM"],"funding":["Medical Research Council","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["68"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3123200"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5"],"pubmed_abstract":["<h4>Background</h4>Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important. Antimicrobial peptides represent a source of potential novel antibiotics to combat resistant bacteria such as Methicillin-Resistant Staphylococcus aureus (MRSA). A promising antimicrobial peptide is ranalexin, which has potent activity against Gram-positive bacteria, and particularly S. aureus. Understanding mode of action is a key component of drug discovery and network biology approaches enable a global, integrated view of microbial physiology, including mechanisms of antibiotic killing. We developed a systems-wide functional association network approach to integrate proteome and transcriptome profiles,"],"journal":["BMC systems biology"],"pubmed_title":["Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus."],"pmcid":["PMC3123200"],"funding_grant_id":["BBS/B/14426","086547","BBS/B/14434"],"pubmed_authors":["Botting CH","Shirran S","Overton IM","Graham S","Coote PJ","Hinds J","Barton GJ","Gould KA"],"additional_accession":[]},"is_claimable":false,"name":"Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus.","description":"<h4>Background</h4>Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important. Antimicrobial peptides represent a source of potential novel antibiotics to combat resistant bacteria such as Methicillin-Resistant Staphylococcus aureus (MRSA). A promising antimicrobial peptide is ranalexin, which has potent activity against Gram-positive bacteria, and particularly S. aureus. Understanding mode of action is a key component of drug discovery and network biology approaches enable a global, integrated view of microbial physiology, including mechanisms of antibiotic killing. We developed a systems-wide functional association network approach to integrate proteome and transcriptome profiles,","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 May","modification":"2026-04-07T15:23:29.981Z","creation":"2019-03-27T00:43:00Z"},"accession":"S-EPMC3123200","cross_references":{"pubmed":["21569391"],"doi":["10.1186/1752-0509-5-68"]}}