biostudies-literatureOverton IMMedical Research CouncilWellcome TrustBiotechnology and Biological Sciences Research Council68https://www.ebi.ac.uk/biostudies/studies/S-EPMC3123200biostudies-literatureUnknown5<h4>Background</h4>Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important. Antimicrobial peptides represent a source of potential novel antibiotics to combat resistant bacteria such as Methicillin-Resistant Staphylococcus aureus (MRSA). A promising antimicrobial peptide is ranalexin, which has potent activity against Gram-positive bacteria, and particularly S. aureus. Understanding mode of action is a key component of drug discovery and network biology approaches enable a global, integrated view of microbial physiology, including mechanisms of antibiotic killing. We developed a systems-wide functional association network approach to integrate proteome and transcriptome profiles,BMC systems biologyGlobal network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus.PMC3123200BBS/B/14426086547BBS/B/14434Botting CHShirran SOverton IMGraham SCoote PJHinds JBarton GJGould KAfalseGlobal network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus.<h4>Background</h4>Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important. Antimicrobial peptides represent a source of potential novel antibiotics to combat resistant bacteria such as Methicillin-Resistant Staphylococcus aureus (MRSA). A promising antimicrobial peptide is ranalexin, which has potent activity against Gram-positive bacteria, and particularly S. aureus. Understanding mode of action is a key component of drug discovery and network biology approaches enable a global, integrated view of microbial physiology, including mechanisms of antibiotic killing. We developed a systems-wide functional association network approach to integrate proteome and transcriptome profiles,2011-01-01T00:00:00Z2011 May2026-04-07T15:23:29.981Z2019-03-27T00:43:00ZS-EPMC31232002156939110.1186/1752-0509-5-68