{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Separovic D"],"funding":["NCRR NIH HHS","NCI NIH HHS"],"pagination":["372-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3123537"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["409(3)"],"pubmed_abstract":["Two anticancer agents, LCL85 and photodynamic therapy (PDT) were combined to test whether the combination PDT/LCL85 evokes changes in the sphingolipid (SL) profile and promotes cell death. Treatment of SCCVII mouse squamous carcinoma cells using the silicone phthalocyanine Pc 4 for PDT induced increases in the prodeath global ceramides/dihydroceramides (DHceramides), and no changes in the prosurvival sphingosine-1-phosphate (S1P). In contrast, after LCL85, the levels of most ceramides and DHceramides were reduced, whereas the levels of S1P were increased. After PDT/LCL85 the levels of global ceramides and DHceramides, and of S1P, were restored to resting levels. PDT/LCL85 also enhanced the levels of C18-, C20-, and C20:1-ceramide, and C18-DHceramide. Treatment with PDT, with or without LCL"],"journal":["Biochemical and biophysical research communications"],"pubmed_title":["Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization."],"pmcid":["PMC3123537"],"funding_grant_id":["P30 CA138313","P01 CA097132","R01 CA77475","IPO1CA097132","P30 CA 138313","P20 RR017677","C06 RR018823","R01 CA077475-11","R01 CA077475"],"pubmed_authors":["Bhatti G","Bielawska A","Bai A","Separovic D","Joseph N","Buren EV","Breen P","Pierce JS","Saad ZH","Bielawski J"],"additional_accession":[]},"is_claimable":false,"name":"Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization.","description":"Two anticancer agents, LCL85 and photodynamic therapy (PDT) were combined to test whether the combination PDT/LCL85 evokes changes in the sphingolipid (SL) profile and promotes cell death. Treatment of SCCVII mouse squamous carcinoma cells using the silicone phthalocyanine Pc 4 for PDT induced increases in the prodeath global ceramides/dihydroceramides (DHceramides), and no changes in the prosurvival sphingosine-1-phosphate (S1P). In contrast, after LCL85, the levels of most ceramides and DHceramides were reduced, whereas the levels of S1P were increased. After PDT/LCL85 the levels of global ceramides and DHceramides, and of S1P, were restored to resting levels. PDT/LCL85 also enhanced the levels of C18-, C20-, and C20:1-ceramide, and C18-DHceramide. Treatment with PDT, with or without LCL","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jun","modification":"2025-04-04T21:57:39.18Z","creation":"2019-03-27T00:43:01Z"},"accession":"S-EPMC3123537","cross_references":{"pubmed":["21545791"],"doi":["10.1016/j.bbrc.2011.04.091"]}}