{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pan D"],"funding":["NIAID NIH HHS","NHLBI NIH HHS","NCI NIH HHS","NINDS NIH HHS"],"pagination":["9168-71"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3124378"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["133(24)"],"pubmed_abstract":["A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus."],"pmcid":["PMC3124378"],"funding_grant_id":["R01 NS059302-05","R01 HL073646-07","HL073646","R01 HL073646","R01 NS059302","CA119342","NS059302","U54 CA119342","N01CO37007"],"pubmed_authors":["Yalaz C","Marsh JN","Pan D","Caruthers SD","Senpan A","Stacy AJ","Hu G","Wickline SA","Lanza GM","Gaffney PJ"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus.","description":"A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jun","modification":"2025-04-04T21:58:29.956Z","creation":"2019-03-27T00:43:03Z"},"accession":"S-EPMC3124378","cross_references":{"pubmed":["21599030"],"doi":["10.1021/ja201918u"]}}