{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(5)"],"submitter":["Mauk MR"],"funding":["Canada Blood Services-Canadian Institute of Health Research Partnership Grant","UMKC RIF","University of Missouri Research Board","NIH","Canadian Institutes of Health Research","Canada Research Chair"],"pubmed_abstract":["Hemopexin is a plasma protein that plays a well-established biological role in sequestering heme that is released into the plasma from hemoglobin and myoglobin as the result of intravascular or extravascular hemolysis as well as from skeletal muscle trauma or neuromuscular disease. In recent years, a variety of additional biological activities have been attributed to hemopexin, for example, hyaluronidase activity, serine protease activity, pro-inflammatory and anti-inflammatory activity as well as suppression of lymphocyte necrosis, inhibition of cellular adhesion, and binding of divalent metal ions. This review examines the challenges involved in the purification of hemopexin from plasma and in the recombinant expression of hemopexin and evaluates the questions that these challenges and t"],"journal":["Protein science : a publication of the Protein Society"],"pagination":["791-805"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3125864"],"repository":["biostudies-literature"],"pubmed_title":["An alternative view of the proposed alternative activities of hemopexin."],"pmcid":["PMC3125864"],"pubmed_authors":["Smith A","Mauk AG","Mauk MR"],"additional_accession":[]},"is_claimable":false,"name":"An alternative view of the proposed alternative activities of hemopexin.","description":"Hemopexin is a plasma protein that plays a well-established biological role in sequestering heme that is released into the plasma from hemoglobin and myoglobin as the result of intravascular or extravascular hemolysis as well as from skeletal muscle trauma or neuromuscular disease. In recent years, a variety of additional biological activities have been attributed to hemopexin, for example, hyaluronidase activity, serine protease activity, pro-inflammatory and anti-inflammatory activity as well as suppression of lymphocyte necrosis, inhibition of cellular adhesion, and binding of divalent metal ions. This review examines the challenges involved in the purification of hemopexin from plasma and in the recombinant expression of hemopexin and evaluates the questions that these challenges and t","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 May","modification":"2025-04-22T20:39:29.971Z","creation":"2019-06-05T16:34:08Z"},"accession":"S-EPMC3125864","cross_references":{"pubmed":["21404362"],"doi":["10.1002/pro.616"]}}