biostudies-literatureFortwendel JRNIAID NIH HHS611-5https://www.ebi.ac.uk/biostudies/studies/S-EPMC3127644biostudies-literatureUnknown10(4)Here we show that expression of a constitutively activated RasA allele, as the sole source of Ras activity, revealed novel Ras-induced phenotypes, including excessive vacuolar expansion and spontaneous lysis of hyphal compartments. These findings highlight the requirement for balanced Ras activity in the establishment and maintenance of polarized growth in filamentous fungi.Eukaryotic cellRegulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.PMC31276445T32-AI052080T32 AI052080Fortwendel JRJuvvadi PRSteinbach WJRogg LEfalseRegulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.Here we show that expression of a constitutively activated RasA allele, as the sole source of Ras activity, revealed novel Ras-induced phenotypes, including excessive vacuolar expansion and spontaneous lysis of hyphal compartments. These findings highlight the requirement for balanced Ras activity in the establishment and maintenance of polarized growth in filamentous fungi.2011-01-01T00:00:00Z2011 Apr2021-03-03T08:55:49Z2019-03-27T03:06:33ZS-EPMC31276442127823010.1128/EC.00315-1010.1128/ec.00315-10