{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["163(5)"],"submitter":["Olliges A"],"pubmed_abstract":["<h4>Background and purpose</h4>Deletion of the cyclooxygenase-2 (COX-2) gene causes impairment of kidney development, but the effect of selective inhibitors of COX-2 (coxibs) or the non-selective inhibitors of COX (the classical non-steroidal anti-inflammatory drugs; NSAIDs) on kidney development was less well described.<h4>Experimental approach</h4>We assessed the effects of equipotent analgesic doses of celecoxib, rofecoxib, valdecoxib, etoricoxib and lumiracoxib and of the NSAIDs, diclofenac and naproxen, on postpartum kidney development in mice, from postnatal day 1 (P1) to P21.<h4>Key results</h4>All the COX inhibitors, at the doses used, blocked COX-2 activity by more than 80% as assayed by PGE(2) synthesis in lipopolysaccharide-stimulated mouse blood samples. Rofecoxib, etoricoxib a"],"journal":["British journal of pharmacology"],"pagination":["927-36"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3130940"],"repository":["biostudies-literature"],"pubmed_title":["Defects in mouse nephrogenesis induced by selective and non-selective cyclooxygenase-2 inhibitors."],"pmcid":["PMC3130940"],"pubmed_authors":["Wimmer S","Olliges A","Nusing RM"],"additional_accession":[]},"is_claimable":false,"name":"Defects in mouse nephrogenesis induced by selective and non-selective cyclooxygenase-2 inhibitors.","description":"<h4>Background and purpose</h4>Deletion of the cyclooxygenase-2 (COX-2) gene causes impairment of kidney development, but the effect of selective inhibitors of COX-2 (coxibs) or the non-selective inhibitors of COX (the classical non-steroidal anti-inflammatory drugs; NSAIDs) on kidney development was less well described.<h4>Experimental approach</h4>We assessed the effects of equipotent analgesic doses of celecoxib, rofecoxib, valdecoxib, etoricoxib and lumiracoxib and of the NSAIDs, diclofenac and naproxen, on postpartum kidney development in mice, from postnatal day 1 (P1) to P21.<h4>Key results</h4>All the COX inhibitors, at the doses used, blocked COX-2 activity by more than 80% as assayed by PGE(2) synthesis in lipopolysaccharide-stimulated mouse blood samples. Rofecoxib, etoricoxib a","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jul","modification":"2025-05-29T21:53:11.814Z","creation":"2019-03-27T03:06:45Z"},"accession":"S-EPMC3130940","cross_references":{"pubmed":["21391980"],"doi":["10.1111/j.1476-5381.2011.01313.x"]}}