biostudies-literatureUnknown163(5)Olliges A<h4>Background and purpose</h4>Deletion of the cyclooxygenase-2 (COX-2) gene causes impairment of kidney development, but the effect of selective inhibitors of COX-2 (coxibs) or the non-selective inhibitors of COX (the classical non-steroidal anti-inflammatory drugs; NSAIDs) on kidney development was less well described.<h4>Experimental approach</h4>We assessed the effects of equipotent analgesic doses of celecoxib, rofecoxib, valdecoxib, etoricoxib and lumiracoxib and of the NSAIDs, diclofenac and naproxen, on postpartum kidney development in mice, from postnatal day 1 (P1) to P21.<h4>Key results</h4>All the COX inhibitors, at the doses used, blocked COX-2 activity by more than 80% as assayed by PGE(2) synthesis in lipopolysaccharide-stimulated mouse blood samples. Rofecoxib, etoricoxib aBritish journal of pharmacology927-36https://www.ebi.ac.uk/biostudies/studies/S-EPMC3130940biostudies-literatureDefects in mouse nephrogenesis induced by selective and non-selective cyclooxygenase-2 inhibitors.PMC3130940Wimmer SOlliges ANusing RMfalseDefects in mouse nephrogenesis induced by selective and non-selective cyclooxygenase-2 inhibitors.<h4>Background and purpose</h4>Deletion of the cyclooxygenase-2 (COX-2) gene causes impairment of kidney development, but the effect of selective inhibitors of COX-2 (coxibs) or the non-selective inhibitors of COX (the classical non-steroidal anti-inflammatory drugs; NSAIDs) on kidney development was less well described.<h4>Experimental approach</h4>We assessed the effects of equipotent analgesic doses of celecoxib, rofecoxib, valdecoxib, etoricoxib and lumiracoxib and of the NSAIDs, diclofenac and naproxen, on postpartum kidney development in mice, from postnatal day 1 (P1) to P21.<h4>Key results</h4>All the COX inhibitors, at the doses used, blocked COX-2 activity by more than 80% as assayed by PGE(2) synthesis in lipopolysaccharide-stimulated mouse blood samples. Rofecoxib, etoricoxib a2011-01-01T00:00:00Z2011 Jul2025-05-29T21:53:11.814Z2019-03-27T03:06:45ZS-EPMC31309402139198010.1111/j.1476-5381.2011.01313.x