{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4"],"submitter":["Conzelmann N"],"pubmed_abstract":["<h4>Background</h4>Granulocyte-colony stimulating factor (G-CSF) is one of the most important pharmacologically used proteins. Potential uses beyond the stimulation of neutrophilic granulocytes are the treatment of CNS disorders. Disadvantages of the G-CSF protein as a drug are its moderate plasma half-life time and considerable production costs. We therefore conducted a screen for peptide agonists derived from the sequence of human G-CSF.<h4>Findings</h4>Despite of the high sensitivity of our screening system we could not detect any positive hits in a single peptide approach. In a multiplex approach using a permutation of any combination of 10 different peptides we could also not detect a positive block.<h4>Conclusions</h4>We conclude that larger coherent parts of the protein or dimerisin"],"journal":["BMC research notes"],"pagination":["194"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3132715"],"repository":["biostudies-literature"],"pubmed_title":["A screen for peptide agonists of the G-CSF receptor."],"pmcid":["PMC3132715"],"pubmed_authors":["Conzelmann N","Schneider A"],"additional_accession":[]},"is_claimable":false,"name":"A screen for peptide agonists of the G-CSF receptor.","description":"<h4>Background</h4>Granulocyte-colony stimulating factor (G-CSF) is one of the most important pharmacologically used proteins. Potential uses beyond the stimulation of neutrophilic granulocytes are the treatment of CNS disorders. Disadvantages of the G-CSF protein as a drug are its moderate plasma half-life time and considerable production costs. We therefore conducted a screen for peptide agonists derived from the sequence of human G-CSF.<h4>Findings</h4>Despite of the high sensitivity of our screening system we could not detect any positive hits in a single peptide approach. In a multiplex approach using a permutation of any combination of 10 different peptides we could also not detect a positive block.<h4>Conclusions</h4>We conclude that larger coherent parts of the protein or dimerisin","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jun","modification":"2025-05-29T20:30:19.394Z","creation":"2019-03-27T03:06:54Z"},"accession":"S-EPMC3132715","cross_references":{"pubmed":["21676239"],"doi":["10.1186/1756-0500-4-194"]}}