{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Muniz LR"],"funding":["NIDDK NIH HHS"],"pagination":["828-34"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3137511"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["187(2)"],"pubmed_abstract":["Ectopic, or tertiary, lymphoid aggregates often form in chronically inflamed areas. Lymphatic vessels, as well as high endothelial venules, form within these lymphoid aggregates, but the mechanisms underlying their development are poorly understood. Overexpression of the chemokine CCL21 in the thyroid of transgenic mice leads to formation of lymphoid aggregates containing topologically segregated T and B lymphocytes, dendritic cells (DCs), and specialized vasculature, including Lyve-1(+)/Prox-1(+) lymphatic vessels. In this article, we show that adoptive transfer of mature CD4(+) T cells into animals expressing CCL21 in a RAG-deficient background promotes the influx of host NK cells and DCs into the thyroid and the formation of new lymphatic vessels within 10 d. This process is dependent o"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["A critical role for dendritic cells in the formation of lymphatic vessels within tertiary lymphoid structures."],"pmcid":["PMC3137511"],"funding_grant_id":["R01 DK067989-08","DK 067989","R01 DK067381","R01 DK067989"],"pubmed_authors":["Pacer ME","Muniz LR","Lira SA","Furtado GC"],"additional_accession":[]},"is_claimable":false,"name":"A critical role for dendritic cells in the formation of lymphatic vessels within tertiary lymphoid structures.","description":"Ectopic, or tertiary, lymphoid aggregates often form in chronically inflamed areas. Lymphatic vessels, as well as high endothelial venules, form within these lymphoid aggregates, but the mechanisms underlying their development are poorly understood. Overexpression of the chemokine CCL21 in the thyroid of transgenic mice leads to formation of lymphoid aggregates containing topologically segregated T and B lymphocytes, dendritic cells (DCs), and specialized vasculature, including Lyve-1(+)/Prox-1(+) lymphatic vessels. In this article, we show that adoptive transfer of mature CD4(+) T cells into animals expressing CCL21 in a RAG-deficient background promotes the influx of host NK cells and DCs into the thyroid and the formation of new lymphatic vessels within 10 d. This process is dependent o","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jul","modification":"2025-04-04T23:41:31.49Z","creation":"2019-03-27T03:07:08Z"},"accession":"S-EPMC3137511","cross_references":{"pubmed":["21666055"],"doi":["10.4049/jimmunol.1004233"]}}