{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chuang JC"],"funding":["NCRR NIH HHS","NIDDK NIH HHS"],"pagination":["1482-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3138640"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["141(8)"],"pubmed_abstract":["Half-lives of α-tocopherol in plasma have been reported as 2-3 d, whereas the Elgin Study required >2 y to deplete α-tocopherol, so gaps exist in our quantitative understanding of human α-tocopherol metabolism. Therefore, 6 men and 6 women aged 27 ± 6 y (mean ± SD) ingested 1.81 nmol, 3.70 kBq of [5-(14)CH(3)]-(2R, 4'R, 8'R)-α-tocopherol. The levels of (14)C in blood plasma and washed RBC were monitored frequently from 0 to 460 d while the levels of (14)C in urine and feces were monitored from 0 to 21 d. Total fecal elimination (fecal + metabolic fecal) was 23.24 ± 5.81% of the (14)C dose, so feces over urine was the major route of elimination of the ingested [5-(14)CH(3)]-(2R, 4'R, 8'R)-α-tocopherol, consistent with prior estimates. The half-life of α-tocopherol varied in plasma and RBC a"],"journal":["The Journal of nutrition"],"pubmed_title":["Quantitation of [5-14CH3]-(2R, 4'R, 8'R)-α-tocopherol in humans."],"pmcid":["PMC3138640"],"funding_grant_id":["R01 DK081551","P41 RR013461","R01 DK 081551","UL1 RR024146","RR13461"],"pubmed_authors":["Chuang JC","Clifford AJ","Kim SH","Fadel JG","Nambiar KP","Holstege DM","Matel HD"],"additional_accession":[]},"is_claimable":false,"name":"Quantitation of [5-14CH3]-(2R, 4'R, 8'R)-α-tocopherol in humans.","description":"Half-lives of α-tocopherol in plasma have been reported as 2-3 d, whereas the Elgin Study required >2 y to deplete α-tocopherol, so gaps exist in our quantitative understanding of human α-tocopherol metabolism. Therefore, 6 men and 6 women aged 27 ± 6 y (mean ± SD) ingested 1.81 nmol, 3.70 kBq of [5-(14)CH(3)]-(2R, 4'R, 8'R)-α-tocopherol. The levels of (14)C in blood plasma and washed RBC were monitored frequently from 0 to 460 d while the levels of (14)C in urine and feces were monitored from 0 to 21 d. Total fecal elimination (fecal + metabolic fecal) was 23.24 ± 5.81% of the (14)C dose, so feces over urine was the major route of elimination of the ingested [5-(14)CH(3)]-(2R, 4'R, 8'R)-α-tocopherol, consistent with prior estimates. The half-life of α-tocopherol varied in plasma and RBC a","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Aug","modification":"2025-04-05T10:03:19.421Z","creation":"2019-03-27T03:07:12Z"},"accession":"S-EPMC3138640","cross_references":{"pubmed":["21715470"],"doi":["10.3945/jn.111.138925"]}}