{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(7)"],"submitter":["Millucci L"],"pubmed_abstract":["<h4>Aims</h4>Atrial Natriuretic Peptide (ANP)-containing amyloid is frequently found in the elderly heart. No data exist regarding ANP aggregation process and its link to pathologies. Our aims were: i) to experimentally prove the presumptive association of Congestive Heart Failure (CHF) and Isolated Atrial Amyloidosis (IAA); ii) to characterize ANP aggregation, thereby elucidating IAA implication in the CHF pathogenesis.<h4>Methods and results</h4>A significant prevalence (85%) of IAA was immunohistochemically proven ex vivo in biopsies from CHF patients. We investigated in vitro (using Congo Red, Thioflavin T, SDS-PAGE, transmission electron microscopy, infrared spectroscopy) ANP fibrillogenesis, starting from α-ANP as well as the ability of dimeric β-ANP to promote amyloid formation. Dif"],"journal":["PloS one"],"pagination":["e21870"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3144199"],"repository":["biostudies-literature"],"pubmed_title":["Different factors affecting human ANP amyloid aggregation and their implications in congestive heart failure."],"pmcid":["PMC3144199"],"pubmed_authors":["Tanganelli P","Santucci A","Ghezzi L","Laschi M","Consumi M","Spreafico A","Braconi D","Magnani A","Bernardini G","Millucci L","Lupetti P","Paccagnini E"],"additional_accession":[]},"is_claimable":false,"name":"Different factors affecting human ANP amyloid aggregation and their implications in congestive heart failure.","description":"<h4>Aims</h4>Atrial Natriuretic Peptide (ANP)-containing amyloid is frequently found in the elderly heart. No data exist regarding ANP aggregation process and its link to pathologies. Our aims were: i) to experimentally prove the presumptive association of Congestive Heart Failure (CHF) and Isolated Atrial Amyloidosis (IAA); ii) to characterize ANP aggregation, thereby elucidating IAA implication in the CHF pathogenesis.<h4>Methods and results</h4>A significant prevalence (85%) of IAA was immunohistochemically proven ex vivo in biopsies from CHF patients. We investigated in vitro (using Congo Red, Thioflavin T, SDS-PAGE, transmission electron microscopy, infrared spectroscopy) ANP fibrillogenesis, starting from α-ANP as well as the ability of dimeric β-ANP to promote amyloid formation. Dif","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011","modification":"2025-05-31T22:43:29.123Z","creation":"2025-05-31T22:43:29.123Z"},"accession":"S-EPMC3144199","cross_references":{"pubmed":["21814559"],"doi":["10.1371/journal.pone.0021870"]}}