{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["121(8)"],"submitter":["Pan SH"],"pubmed_abstract":["Metastasis is a predominant cause of death in patients with cancer. It is a complex multistep process that needs to be better understood if we are to develop new approaches to managing tumor metastasis. Tumor cell invasion of the local stroma is suppressed by collapsin response mediator protein-1 (CRMP-1). Recently, we identified a long isoform of CRMP-1 (LCRMP-1), expression of which correlates with cancer cell invasiveness and poor clinical outcome in patients with non-small-cell lung cancer (NSCLC). Here, we report that LCRMP-1 overexpression in noninvasive human cell lines enhanced filopodia formation, cancer cell migration, and invasion via stabilization of actin. This effect required a highly conserved N-terminal region of LCRMP-1 as well as the WASP family verprolin-homologous prote"],"journal":["The Journal of clinical investigation"],"pagination":["3189-205"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3148721"],"repository":["biostudies-literature"],"pubmed_title":["The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1."],"pmcid":["PMC3148721"],"pubmed_authors":["Chan WK","Yang SC","Chang YL","Kuo ML","Chen JJ","Wu CT","Che TF","Lin CY","Lee YC","Chang CC","Hong TM","Wang WL","Chao YC","Lee CH","Pan SH","Hung PF","Chen HY","Yang PC","Wu YY","Wang LK"],"additional_accession":[]},"is_claimable":false,"name":"The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1.","description":"Metastasis is a predominant cause of death in patients with cancer. It is a complex multistep process that needs to be better understood if we are to develop new approaches to managing tumor metastasis. Tumor cell invasion of the local stroma is suppressed by collapsin response mediator protein-1 (CRMP-1). Recently, we identified a long isoform of CRMP-1 (LCRMP-1), expression of which correlates with cancer cell invasiveness and poor clinical outcome in patients with non-small-cell lung cancer (NSCLC). Here, we report that LCRMP-1 overexpression in noninvasive human cell lines enhanced filopodia formation, cancer cell migration, and invasion via stabilization of actin. This effect required a highly conserved N-terminal region of LCRMP-1 as well as the WASP family verprolin-homologous prote","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Aug","modification":"2025-04-21T13:57:31.615Z","creation":"2019-03-27T03:07:40Z"},"accession":"S-EPMC3148721","cross_references":{"pubmed":["21747164"],"doi":["10.1172/JCI42975","10.1172/jci42975"]}}