{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mattapallil MJ"],"funding":["Intramural NIH HHS","NEI NIH HHS","NIDCR NIH HHS","NIAID NIH HHS"],"pagination":["1977-85"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3150271"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["187(4)"],"pubmed_abstract":["Noninfectious uveitis is a leading cause of blindness and thought to involve autoimmune T cell responses to retinal proteins (e.g., retinal arrestin [soluble-Ag (S-Ag)]). There are no known biomarkers for the disease. Susceptibility is associated with HLA, but little is known about susceptible class II alleles or the potentially pathogenic epitopes that they present. Using a humanized HLA-transgenic mouse model of S-Ag-induced autoimmune uveitis, we identified several susceptible and resistant alleles of HLA-DR and -DQ genes and defined pathogenic epitopes of S-Ag presented by the susceptible alleles. The sequences of these epitopes overlap with some previously identified peptides of S-Ag (\"M\" and \"N\"), known to elicit memory responses in lymphocytes of uveitis patients. HLA-DR-restricted,"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells."],"pmcid":["PMC3150271"],"funding_grant_id":["R01 EY006225","ZIC EY000457-03","R01 DE019397-03","R01 DE019397-02","R01 EY014864","EY006225","R21DE018339","R21 DE018339","R21 DE018339-02","R21 DE018339-01","EY014864","R01 DE019397-01A2","R21 DE018339-02S1","ZIA EY000184-28","K22AI07812","Z99 EY999999","R01 DE019397"],"pubmed_authors":["David CS","Karabekian Z","Mattapallil JJ","Kwok WW","Mattapallil MJ","Chan CC","McDowell JH","Silver PB","Sen HN","James EA","Caspi RR","Horai R","Nussenblatt RB"],"additional_accession":[]},"is_claimable":false,"name":"Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells.","description":"Noninfectious uveitis is a leading cause of blindness and thought to involve autoimmune T cell responses to retinal proteins (e.g., retinal arrestin [soluble-Ag (S-Ag)]). There are no known biomarkers for the disease. Susceptibility is associated with HLA, but little is known about susceptible class II alleles or the potentially pathogenic epitopes that they present. Using a humanized HLA-transgenic mouse model of S-Ag-induced autoimmune uveitis, we identified several susceptible and resistant alleles of HLA-DR and -DQ genes and defined pathogenic epitopes of S-Ag presented by the susceptible alleles. The sequences of these epitopes overlap with some previously identified peptides of S-Ag (\"M\" and \"N\"), known to elicit memory responses in lymphocytes of uveitis patients. HLA-DR-restricted,","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Aug","modification":"2025-04-21T13:51:51.069Z","creation":"2019-03-27T03:07:43Z"},"accession":"S-EPMC3150271","cross_references":{"pubmed":["21765017"],"doi":["10.4049/jimmunol.1101247"]}}