{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schott JM"],"funding":["NIA NIH HHS","National Institute for Health Research (NIHR)","National Institutes of Health","NIH","Dana Foundation"],"pagination":["1486.e9-15"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3150628"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(7)"],"pubmed_abstract":["Defining cases and controls on the basis of biomarkers rather than clinical diagnosis may reduce sample sizes required for genetic studies. The aim of this study was to assess whether characterizing case/control status on the basis of cerebrospinal fluid (CSF) profile would increase power to replicate known genetic associations for Alzheimer's disease (AD). Independent of clinical diagnosis, Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects with 2 CSF biomarkers for AD (Aβ1-42 < 192 pg/mL and tau phosphorylated at threonine 181 (p-tau) > 23 pg/mL, \"CSF-positive\") were compared with those without CSF evidence for AD (Aβ1-42 > 192 pg/mL and 181-phosphorylated tau < 23 pg/mL, \"CSF-negative\"). Minor allele frequency (MAF) and odds ratios (ORs) between these 2 groups were calculated f"],"journal":["Neurobiology of aging"],"pubmed_title":["Using CSF biomarkers to replicate genetic associations in Alzheimer's disease."],"pmcid":["PMC3150628"],"funding_grant_id":["U01 AG024904","U19 AG010483","K01 AG030514","P30 AG010129"],"pubmed_authors":["Rodriguez-Vieitez E","Rulseh A","Rhinn H","Speier W","Brewer J","Devanarayan V","Depy Carron D","Lane B","Svetnik V","Haas M","Lobach I","Battaglini I","Yuan Y","Mathis C","Korolev I","Ma SL","Sherer E","Voineskos A","Ma SM","Thames A","Tauber C","Wang YM","Martins R","Hochstetler H","Levey A","Fletcher E","Steenland N","Decker S","Priya K","Schwarz A","Bartlett J","Symons S","Boot B","Zhu Z","Yu P","Wittemer E","Gillespie W","Summers D","Bjornsdotter M","Shilaskar S","Huentelman M","Sotolongo-Grau O","Ramirez A","Liao S","Suen S","Toledo JB","Schwarz J","White B","Kanchev V","Aksu Y","Forsythe A","Ayan-Oshodi M","Yamashita F","Wishart 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The aim of this study was to assess whether characterizing case/control status on the basis of cerebrospinal fluid (CSF) profile would increase power to replicate known genetic associations for Alzheimer's disease (AD). Independent of clinical diagnosis, Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects with 2 CSF biomarkers for AD (Aβ1-42 < 192 pg/mL and tau phosphorylated at threonine 181 (p-tau) > 23 pg/mL, \"CSF-positive\") were compared with those without CSF evidence for AD (Aβ1-42 > 192 pg/mL and 181-phosphorylated tau < 23 pg/mL, \"CSF-negative\"). Minor allele frequency (MAF) and odds ratios (ORs) between these 2 groups were calculated f","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jul","modification":"2026-05-03T12:26:39.937Z","creation":"2019-03-27T03:07:47Z"},"accession":"S-EPMC3150628","cross_references":{"pubmed":["21459483"],"doi":["10.1016/j.neurobiolaging.2011.02.008"]}}