{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":54,"searchCount":0},"additional":{"submitter":["Mudrak B"],"funding":["NIAID NIH HHS"],"pagination":["1445-70"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3153253"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(6)"],"pubmed_abstract":["Enterotoxigenic Escherichia coli (ETEC) is a significant source of morbidity and mortality worldwide. One major virulence factor released by ETEC is the heat-labile enterotoxin LT, which is structurally and functionally similar to cholera toxin. LT consists of five B subunits carrying a single catalytically active A subunit. LTB binds the monosialoganglioside G(M1), the toxin's host receptor, but interactions with A-type blood sugars and E. coli lipopolysaccharide have also been identified within the past decade. Here, we review the regulation, assembly, and binding properties of the LT B-subunit pentamer and discuss the possible roles of its numerous molecular interactions."],"journal":["Toxins"],"pubmed_title":["Heat-labile enterotoxin: beyond G(m1) binding."],"pmcid":["PMC3153253"],"funding_grant_id":["R01AI064464","R01AI079068","R01 AI079068","R01 AI064464"],"pubmed_authors":["Kuehn MJ","Mudrak B"],"view_count":["54"],"additional_accession":[]},"is_claimable":false,"name":"Heat-labile enterotoxin: beyond G(m1) binding.","description":"Enterotoxigenic Escherichia coli (ETEC) is a significant source of morbidity and mortality worldwide. One major virulence factor released by ETEC is the heat-labile enterotoxin LT, which is structurally and functionally similar to cholera toxin. LT consists of five B subunits carrying a single catalytically active A subunit. LTB binds the monosialoganglioside G(M1), the toxin's host receptor, but interactions with A-type blood sugars and E. coli lipopolysaccharide have also been identified within the past decade. Here, we review the regulation, assembly, and binding properties of the LT B-subunit pentamer and discuss the possible roles of its numerous molecular interactions.","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jun","modification":"2024-11-20T18:53:23.971Z","creation":"2019-03-27T03:07:51Z"},"accession":"S-EPMC3153253","cross_references":{"pubmed":["22069646"],"doi":["10.3390/toxins2061445"]}}