{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Becker JT"],"funding":["NCRR NIH HHS","NIAID NIH HHS","NIMH NIH HHS"],"pagination":["113-21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3154580"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["54(2)"],"pubmed_abstract":["The purpose of this study was to characterize brain volumetric differences in HIV seropositive and seronegative men and to determine effects of age, cardiovascular risk, and HIV infection on structural integrity.Magnetic resonance imaging was used to acquire high-resolution neuroanatomic data in 160 men aged 50 years and over, including 84 HIV seropositive and 76 seronegative controls. Voxel-based morphometry was used to derive volumetric measurements at the level of the individual voxel. Data from a detailed neuropsychological test battery were recombined into four summary scores representing psychomotor speed, visual memory, verbal memory, and verbal fluency.Both age and HIV status had a significant effect on both gray matter (GM) and white matter (WM) volume. The age-related GM atrophy was primarily in the superior temporal and inferior frontal regions; the HIV-related GM loss included the posterior and inferior temporal lobes, the parietal lobes, and the cerebellum. Among all subjects, the performance on neuropsychological tests, as indexed by a summary variable, was related to the volume of both the GM and WM. Contrary to our predictions, the CVD variables were not linked to brain volume in statistically adjusted models.In the post-HAART era, having HIV infection is still linked to atrophy in both GM and WM. Secondly, advancing age, even in this relatively young cohort, is also linked to changes in GM and WM volume. Thirdly, CNS structural integrity is associated with overall cognitive functions, regardless of the HIV infection status of the study volunteers."],"journal":["Neuroradiology"],"pubmed_title":["Factors affecting brain structure in men with HIV disease in the post-HAART era."],"pmcid":["PMC3154580"],"funding_grant_id":["M01 RR000052","UO1-AI-37984","U01 AI037984","R01 MH080636","U01 AI035041","U01 AI035040","U01 AI035043","U01 AI035042","U01 AI037984-08","U01 AI035043-17","U01 AI035041-19","U01 AI037613","M01 RR000052-46","U01 AI035039","U01 AI037613-08","U01 AI035040-20","UO1-AI-35039","UO1-AI-35040","UO1-AI-35043","U01 AI035039-17","U01 AI035042-17","UO1-AI-35041","UO1-AI-35042","1-AI-37613","5-MO1-RR-00052"],"pubmed_authors":["O'Gorman M","Huebner RE","Wolinsky SM","Satz P","Variakojis D","Kingsley LA","Dobs A","Cole SR","Detels R","Su S","Martin E","Goodkin K","Maruca V","Effros R","Sacktor N","Visscher BR","Rinaldo CR","Badri S","Oishi J","Gange SJ","Phair JP","Wiley D","Thio C","McDonald C","Breen E","Sanders JM","Schollenberger J","Fahey J","Vinters H","Becker JT","Mellors JW","Stall RD","Selnes O","Young S","Butch A","Yang O","Barker PB","Jamieson B","Cranston RD","Johnson L","Margolick JB","Armenian H","Conover C","Hylton J","Alger JR","Martinson JJ","Brouwers P","Gallant J","Multicenter AIDS Cohort Study","Ostrow D","Bolan R","Munoz A","Ragin A","Martinez-Maza O","Miller EN","Seaberg EC","Jacobson LP","Silvestre AJ","Crain B","Cox C","Witt M","Palella F","D'Souza G","Cohen B","Zhang ZF","Dominguez G","Shepard J","Chmiel JS","Lai S","Coates T","Farzadegan H","Aaronow A"],"additional_accession":[]},"is_claimable":false,"name":"Factors affecting brain structure in men with HIV disease in the post-HAART era.","description":"The purpose of this study was to characterize brain volumetric differences in HIV seropositive and seronegative men and to determine effects of age, cardiovascular risk, and HIV infection on structural integrity.Magnetic resonance imaging was used to acquire high-resolution neuroanatomic data in 160 men aged 50 years and over, including 84 HIV seropositive and 76 seronegative controls. Voxel-based morphometry was used to derive volumetric measurements at the level of the individual voxel. Data from a detailed neuropsychological test battery were recombined into four summary scores representing psychomotor speed, visual memory, verbal memory, and verbal fluency.Both age and HIV status had a significant effect on both gray matter (GM) and white matter (WM) volume. The age-related GM atrophy was primarily in the superior temporal and inferior frontal regions; the HIV-related GM loss included the posterior and inferior temporal lobes, the parietal lobes, and the cerebellum. Among all subjects, the performance on neuropsychological tests, as indexed by a summary variable, was related to the volume of both the GM and WM. Contrary to our predictions, the CVD variables were not linked to brain volume in statistically adjusted models.In the post-HAART era, having HIV infection is still linked to atrophy in both GM and WM. Secondly, advancing age, even in this relatively young cohort, is also linked to changes in GM and WM volume. Thirdly, CNS structural integrity is associated with overall cognitive functions, regardless of the HIV infection status of the study volunteers.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Feb","modification":"2020-10-29T14:18:37Z","creation":"2019-03-27T03:07:54Z"},"accession":"S-EPMC3154580","cross_references":{"pubmed":["21424708"],"doi":["10.1007/s00234-011-0854-2"]}}