{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(13)"],"submitter":["Brenner S"],"pubmed_abstract":["The quality and quantity of BCR signals impact on cell fate decisions of B lymphocytes. Here, we describe novel gene-targeted mice, which in the context of normal VDJ recombination show hypomorphic expression of immunoglobulin μ heavy chain (μHC) mRNA levels and hence lower pre-BCR and BCR levels. Hypomorphic expression of μHC leads to augmented selection processes at all stages of B-cell development, noticeably at the expansion of pre-B cells, the positive selection of immature B lymphocytes in the bone marrow and the selection of the follicular (FO), marginal zone (MZ) and B1 B-lymphocyte compartment in peripheral lymphoid organs. Immature as well as mature FO and MZ B lymphocytes in the peripheral lymphoid organs express lower levels of the receptor for B-cell activating factor (BAFF). "],"journal":["The EMBO journal"],"pagination":["2705-18"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3155302"],"repository":["biostudies-literature"],"pubmed_title":["A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing."],"pmcid":["PMC3155302"],"pubmed_authors":["Steinbart T","Welzel H","Yu P","Brenner S","Drewel D","Nitschke L","Weisel F","Schweizer A","Hartel E","Potzsch S","Brandl A","Mudde GC","Winkler TH"],"additional_accession":[]},"is_claimable":false,"name":"A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing.","description":"The quality and quantity of BCR signals impact on cell fate decisions of B lymphocytes. Here, we describe novel gene-targeted mice, which in the context of normal VDJ recombination show hypomorphic expression of immunoglobulin μ heavy chain (μHC) mRNA levels and hence lower pre-BCR and BCR levels. Hypomorphic expression of μHC leads to augmented selection processes at all stages of B-cell development, noticeably at the expansion of pre-B cells, the positive selection of immature B lymphocytes in the bone marrow and the selection of the follicular (FO), marginal zone (MZ) and B1 B-lymphocyte compartment in peripheral lymphoid organs. Immature as well as mature FO and MZ B lymphocytes in the peripheral lymphoid organs express lower levels of the receptor for B-cell activating factor (BAFF). ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 May","modification":"2025-05-29T20:29:03.376Z","creation":"2019-03-27T03:07:57Z"},"accession":"S-EPMC3155302","cross_references":{"pubmed":["21623346"],"doi":["10.1038/emboj.2011.168"]}}