biostudies-literatureZencir SNIDDK NIH HHS792-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC3157015biostudies-literatureUnknown411(4)The vast majority of physiological processes in living cells are mediated by protein-protein interactions often specified by particular protein sequence motifs. PDZ domains, composed of 80-100 amino acid residues, are an important class of interaction motif. Among the PDZ-containing proteins, glutaminase interacting protein (GIP), also known as Tax Interacting Protein TIP-1, is unique in being composed almost exclusively of a single PDZ domain. GIP has important roles in cellular signaling, protein scaffolding and modulation of tumor growth and interacts with a number of physiological partner proteins, including Glutaminase L, β-Catenin, FAS, HTLV-1 Tax, HPV16 E6, Rhotekin and Kir 2.3. To identify the network of proteins that interact with GIP, a human fetal brain cDNA library was screenedBiochemical and biophysical research communicationsIdentification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein.PMC3157015DK082397R21 DK082397-01R21 DK082397-02R21 DK082397Mohanty SZencir SOvee MBanerjee MDobson MJTopcu ZfalseIdentification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein.The vast majority of physiological processes in living cells are mediated by protein-protein interactions often specified by particular protein sequence motifs. PDZ domains, composed of 80-100 amino acid residues, are an important class of interaction motif. Among the PDZ-containing proteins, glutaminase interacting protein (GIP), also known as Tax Interacting Protein TIP-1, is unique in being composed almost exclusively of a single PDZ domain. GIP has important roles in cellular signaling, protein scaffolding and modulation of tumor growth and interacts with a number of physiological partner proteins, including Glutaminase L, β-Catenin, FAS, HTLV-1 Tax, HPV16 E6, Rhotekin and Kir 2.3. To identify the network of proteins that interact with GIP, a human fetal brain cDNA library was screened2011-01-01T00:00:00Z2011 Aug2025-04-04T21:20:07.65Z2019-03-27T03:08:01ZS-EPMC31570152178775010.1016/j.bbrc.2011.07.029