{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Botti E"],"funding":["NIAID NIH HHS"],"pagination":["13710-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3158164"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["108(33)"],"pubmed_abstract":["The transcription factor interferon regulatory factor 6 (IRF6) regulates craniofacial development and epidermal proliferation. We recently showed that IRF6 is a component of a regulatory feedback loop that controls the proliferative potential of epidermal cells. IRF6 is transcriptionally activated by p63 and induces its proteasome-mediated down-regulation, thereby limiting keratinocyte proliferative potential. We hypothesized that IRF6 may also be involved in skin carcinogenesis. Hence, we analyzed IRF6 expression in a large series of squamous cell carcinomas (SCCs) and found a strong down-regulation of IRF6 that correlated with tumor invasive and differentiation status. IRF6 down-regulation in SCC cell lines and primary tumors correlates with methylation on a CpG dinucleotide island locat"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas."],"pmcid":["PMC3158164"],"funding_grant_id":["R37 AI043477","AI043477","R01 AI043477"],"pubmed_authors":["Spallone G","Fanciulli M","Blandino G","Moretti F","Marinari B","Castrignano T","De Meo PD","De Nicola F","Pesole G","Pinetti V","Chimenti S","Guerrini L","Costanzo A","Ganci F","Botti E","Galanti S","Karin M"],"additional_accession":[]},"is_claimable":false,"name":"Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas.","description":"The transcription factor interferon regulatory factor 6 (IRF6) regulates craniofacial development and epidermal proliferation. We recently showed that IRF6 is a component of a regulatory feedback loop that controls the proliferative potential of epidermal cells. IRF6 is transcriptionally activated by p63 and induces its proteasome-mediated down-regulation, thereby limiting keratinocyte proliferative potential. We hypothesized that IRF6 may also be involved in skin carcinogenesis. Hence, we analyzed IRF6 expression in a large series of squamous cell carcinomas (SCCs) and found a strong down-regulation of IRF6 that correlated with tumor invasive and differentiation status. IRF6 down-regulation in SCC cell lines and primary tumors correlates with methylation on a CpG dinucleotide island locat","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Aug","modification":"2025-07-11T03:04:04.741Z","creation":"2025-07-11T03:04:04.741Z"},"accession":"S-EPMC3158164","cross_references":{"pubmed":["21807998"],"doi":["10.1073/pnas.1110931108"]}}