biostudies-literatureBotti ENIAID NIH HHS13710-5https://www.ebi.ac.uk/biostudies/studies/S-EPMC3158164biostudies-literatureUnknown108(33)The transcription factor interferon regulatory factor 6 (IRF6) regulates craniofacial development and epidermal proliferation. We recently showed that IRF6 is a component of a regulatory feedback loop that controls the proliferative potential of epidermal cells. IRF6 is transcriptionally activated by p63 and induces its proteasome-mediated down-regulation, thereby limiting keratinocyte proliferative potential. We hypothesized that IRF6 may also be involved in skin carcinogenesis. Hence, we analyzed IRF6 expression in a large series of squamous cell carcinomas (SCCs) and found a strong down-regulation of IRF6 that correlated with tumor invasive and differentiation status. IRF6 down-regulation in SCC cell lines and primary tumors correlates with methylation on a CpG dinucleotide island locatProceedings of the National Academy of Sciences of the United States of AmericaDevelopmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas.PMC3158164R37 AI043477AI043477R01 AI043477Spallone GFanciulli MBlandino GMoretti FMarinari BCastrignano TDe Meo PDDe Nicola FPesole GPinetti VChimenti SGuerrini LCostanzo AGanci FBotti EGalanti SKarin MfalseDevelopmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas.The transcription factor interferon regulatory factor 6 (IRF6) regulates craniofacial development and epidermal proliferation. We recently showed that IRF6 is a component of a regulatory feedback loop that controls the proliferative potential of epidermal cells. IRF6 is transcriptionally activated by p63 and induces its proteasome-mediated down-regulation, thereby limiting keratinocyte proliferative potential. We hypothesized that IRF6 may also be involved in skin carcinogenesis. Hence, we analyzed IRF6 expression in a large series of squamous cell carcinomas (SCCs) and found a strong down-regulation of IRF6 that correlated with tumor invasive and differentiation status. IRF6 down-regulation in SCC cell lines and primary tumors correlates with methylation on a CpG dinucleotide island locat2011-01-01T00:00:00Z2011 Aug2025-07-11T03:04:04.741Z2025-07-11T03:04:04.741ZS-EPMC31581642180799810.1073/pnas.1110931108