{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pedchenko TV"],"funding":["NIDDK NIH HHS"],"pagination":["689-96"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3159083"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(6)"],"pubmed_abstract":["Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) is a ligand-binding inducible transcriptional factor linked to carcinogenesis. Important functions of PPARbeta/delta were demonstrated in series of human epithelial cancers; however, its role in lung cancer remains controversial. We investigated the differential expression level and localization of PPARbeta/delta in tumors and adjacent normal lung tissue, and the effect of PPARbeta/delta activation on lung cancer cell proliferation and apoptosis. PPARbeta/delta was expressed in all studied human non-small cell lung cancers, and strong PPARbeta/delta immunoreactivity was observed in epithelial cells of more than 75% of studied lung tumors. PPARbeta/delta expression was consistently limited to the cancer cells in tumor ti"],"journal":["American journal of respiratory cell and molecular biology"],"pubmed_title":["Peroxisome proliferator-activated receptor beta/delta expression and activation in lung cancer."],"pmcid":["PMC3159083"],"funding_grant_id":["R37 DK047297","R01 DK062112"],"pubmed_authors":["Pedchenko TV","Wang D","Massion PP","Gonzalez AL","DuBois RN"],"additional_accession":[]},"is_claimable":false,"name":"Peroxisome proliferator-activated receptor beta/delta expression and activation in lung cancer.","description":"Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) is a ligand-binding inducible transcriptional factor linked to carcinogenesis. Important functions of PPARbeta/delta were demonstrated in series of human epithelial cancers; however, its role in lung cancer remains controversial. We investigated the differential expression level and localization of PPARbeta/delta in tumors and adjacent normal lung tissue, and the effect of PPARbeta/delta activation on lung cancer cell proliferation and apoptosis. PPARbeta/delta was expressed in all studied human non-small cell lung cancers, and strong PPARbeta/delta immunoreactivity was observed in epithelial cells of more than 75% of studied lung tumors. PPARbeta/delta expression was consistently limited to the cancer cells in tumor ti","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Dec","modification":"2026-07-15T07:05:35.523Z","creation":"2019-03-27T00:43:10Z"},"accession":"S-EPMC3159083","cross_references":{"pubmed":["18566335"],"doi":["10.1165/rcmb.2007-0426OC","10.1165/rcmb.2007-0426oc"]}}