biostudies-literaturePedchenko TVNIDDK NIH HHS689-96https://www.ebi.ac.uk/biostudies/studies/S-EPMC3159083biostudies-literatureUnknown39(6)Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) is a ligand-binding inducible transcriptional factor linked to carcinogenesis. Important functions of PPARbeta/delta were demonstrated in series of human epithelial cancers; however, its role in lung cancer remains controversial. We investigated the differential expression level and localization of PPARbeta/delta in tumors and adjacent normal lung tissue, and the effect of PPARbeta/delta activation on lung cancer cell proliferation and apoptosis. PPARbeta/delta was expressed in all studied human non-small cell lung cancers, and strong PPARbeta/delta immunoreactivity was observed in epithelial cells of more than 75% of studied lung tumors. PPARbeta/delta expression was consistently limited to the cancer cells in tumor tiAmerican journal of respiratory cell and molecular biologyPeroxisome proliferator-activated receptor beta/delta expression and activation in lung cancer.PMC3159083R37 DK047297R01 DK062112Pedchenko TVWang DMassion PPGonzalez ALDuBois RNfalsePeroxisome proliferator-activated receptor beta/delta expression and activation in lung cancer.Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) is a ligand-binding inducible transcriptional factor linked to carcinogenesis. Important functions of PPARbeta/delta were demonstrated in series of human epithelial cancers; however, its role in lung cancer remains controversial. We investigated the differential expression level and localization of PPARbeta/delta in tumors and adjacent normal lung tissue, and the effect of PPARbeta/delta activation on lung cancer cell proliferation and apoptosis. PPARbeta/delta was expressed in all studied human non-small cell lung cancers, and strong PPARbeta/delta immunoreactivity was observed in epithelial cells of more than 75% of studied lung tumors. PPARbeta/delta expression was consistently limited to the cancer cells in tumor ti2008-01-01T00:00:00Z2008 Dec2026-07-15T07:05:35.523Z2019-03-27T00:43:10ZS-EPMC31590831856633510.1165/rcmb.2007-0426OC10.1165/rcmb.2007-0426oc