{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(8)"],"submitter":["Ghosn J"],"pubmed_abstract":["Our objective was to analyze the evolution of resistance mutations (RM) and viral tropism of multi-drug-resistant (MDR) strains detected at primary HIV-1 infection (PHI). MDR HIV strain was defined as the presence of genotypic resistance to at least 1 antiretroviral of the 3 classes. Tropism determinations (CCR5 or CXCR4) were performed on baseline plasma HIV-RNA and/or PBMC-HIV-DNA samples, then during follow-up using population-based sequencing of V3 loop and phenotypic tests. Clonal analysis was performed at baseline for env, RT and protease genes, and for HIV-DNA env gene during follow-up. Five patients were eligible. At baseline, RT, protease and env clones from HIV-RNA and HIV-DNA were highly homogenous for each patient; genotypic tropism was R5 in 3 (A,B,C) and X4 in 2 patients (D,E"],"journal":["PloS one"],"pagination":["e23301"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3160852"],"repository":["biostudies-literature"],"pubmed_title":["X4 tropic multi-drug resistant quasi-species detected at the time of primary HIV-1 infection remain exclusive or at least dominant far from PHI."],"pmcid":["PMC3160852"],"pubmed_authors":["Ravaux I","Abraham B","Rannou MT","Leboucher B","Merrien D","Chambrin V","Drogoul MP","Massip P","Zucman D","Beck-Wirth G","Touam F","Levy Y","Lascoux C","Leport C","Quinsat DT","David F","Morlat P","Galanaud P","Saada M","Drenou B","Granier F","Hussonnois C","Zeng A","Genet C","Choutet P","Rouzioux C","Koffi K","Genet P","Colasante U","Buisson M","Therby A","Chakvetadze C","Cheret A","Lepeu A","Herson S","Obadia M","Girard PM","Chevojon P","Boue F","Stein A","May T","Morelon S","Bonnet E","Bonnet F","Greder Belan A","Bergmann JF","Jacomet C","Audhuy B","Delfraissy JF","Debab Y","Tubiana R","Katlama C","Chemlal K","De Lacroix Szmania I","Gonzales Canali G","Sauser F","Phung B","Houlbert D","Samanon-Bollens D","Dominguez S","Fantin B","Gellen-Dautremer J","Fialaire P","Aissi E","Moreau P","Lamaury I","Salmon D","Godin C","Dupont M","Makhloufi D","Rouveix E","Bentata M","Bodard L","Daniel C","Roudiere L","Abel S","Meyer L","Lemercier Y","Six M","Parrinello M","Ratajczak M","Dupont C","Biron C","Dupont B","Molina JM","Duvivier C","Loze B","Niault M","Cabie A","Ait Mohand H","Timsit J","Raymond S","Nau P","Domart Y","Viard JP","Sobel A","Weiss L","Raymond I","Jardel H","Bonarek M","Boyer L","Folzer A","Compagnucci A","Vinceneux P","Perre P","Wassoumbou S","Lascaux AS","ANRS CO 06 PRIMO cohort","Lemoing V","Jadand C","Bletry O","Pichard E","Poizot-Martin I","Huchon G","Vaillant O","Rouges F","Badsi E","Redelsperger Y","Roche-Sicot J","Beuscart C","Perino C","Girard JJ","Mansouri R","Piroth L","Fuzibet JG","Lepretre A","Jeanblanc F","Chiarello P","Morel P","Hoen B","Allemand J","Gayraud M","Lelievre JD","Merle De Boever C","Simonpoli AM","Fontaine C","Regnier A","Gourdon F","Beck C","Kousignian P","Prudhomme L","Tredup J","Reliquet V","Tattevin P","Baillat V","Antoniotti O","Bazin C","Blanc AP","Thomas R","Lortholary O","Lagarde P","Aristal S","Gerard L","Geffray L","Devidas A","Pierre-Francois S","Louis I","Chaudier B","Souala F","Beytout J","Yazdanpanah Y","Lambert de Cursay G","Simon A","Courtade B","Uludag A","Pichancourt G","Ruel M","Sobesky G","Goujard C","Neuville S","Cotte L","Chavanet C","Garray V","Tourneur M","Perronne V","Livrozet JM","Cua E","Boussard JL","Tempesta S","Boucherit S","Mounoury O","Nouts C","Miailhes P","Dellamonica P","Perronne C","Medus M","Drobacheff C","Oksenhendler E","Verdon R","de Truchis P","Reynes J","Launay O","Allegre T","Raffi F","Slama L","Loison J","Ragnaud JM","Jestin C","Izopet J","Grihon F","Caron F","Trepo C","Gastaut JA","Martha B","Slama B","Sohn C","Clavel C","Chaix ML","Picard O","Saint-Dizier F","Diab G","Bouvet E","Saraux JL","Weinbreck P","Poinsignon Y","Fior R","Rosenthal E","Deveau C","Raffenne L","Bastides F","Diemer M","Aumaitre H","Guillevin L","Sereni D","Bloch M","Campa P","Pialoux G","Galimand J","Chaillou S","Yeni P","Ghosn J","Lafeuillade A","Sordage M","El Alami N","Miodovski C"],"additional_accession":[]},"is_claimable":false,"name":"X4 tropic multi-drug resistant quasi-species detected at the time of primary HIV-1 infection remain exclusive or at least dominant far from PHI.","description":"Our objective was to analyze the evolution of resistance mutations (RM) and viral tropism of multi-drug-resistant (MDR) strains detected at primary HIV-1 infection (PHI). MDR HIV strain was defined as the presence of genotypic resistance to at least 1 antiretroviral of the 3 classes. Tropism determinations (CCR5 or CXCR4) were performed on baseline plasma HIV-RNA and/or PBMC-HIV-DNA samples, then during follow-up using population-based sequencing of V3 loop and phenotypic tests. Clonal analysis was performed at baseline for env, RT and protease genes, and for HIV-DNA env gene during follow-up. Five patients were eligible. At baseline, RT, protease and env clones from HIV-RNA and HIV-DNA were highly homogenous for each patient; genotypic tropism was R5 in 3 (A,B,C) and X4 in 2 patients (D,E","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011","modification":"2026-04-16T19:10:06.506Z","creation":"2026-04-07T14:18:13.551Z"},"accession":"S-EPMC3160852","cross_references":{"pubmed":["21887243"],"doi":["10.1371/journal.pone.0023301"]}}