{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Neely GG"],"funding":["NINDS NIH HHS","NIGMS NIH HHS"],"pagination":["e24343"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3164203"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(8)"],"pubmed_abstract":["Pain is a significant medical concern and represents a major unmet clinical need. The ability to perceive and react to tissue-damaging stimuli is essential in order to maintain bodily integrity in the face of environmental danger. To prevent damage the systems that detect noxious stimuli are therefore under strict evolutionary pressure. We developed a high-throughput behavioral method to identify genes contributing to thermal nociception in the fruit fly and have reported a large-scale screen that identified the Ca²⁺ channel straightjacket (stj) as a conserved regulator of thermal nociception. Here we present the minimal anatomical and neuronal requirements for Drosophila to avoid noxious heat in our novel behavioral paradigm. Bioinformatics analysis of our whole genome data set revealed 2"],"journal":["PloS one"],"pubmed_title":["TrpA1 regulates thermal nociception in Drosophila."],"pmcid":["PMC3164203"],"funding_grant_id":["1 F32GM086207-01","NS038253","F32 GM086207-03","P01 NS044232","NS044232","NS039518","R01 NS038253","R37 NS039518","R01 NS039518","F32 GM086207"],"pubmed_authors":["Costigan M","Woolf CJ","Garrity PA","Keene AC","Chang EC","Neely GG","Rosenzweig M","Duchek P","Wang QP","Aksoy YA","Penninger JM"],"additional_accession":[]},"is_claimable":false,"name":"TrpA1 regulates thermal nociception in Drosophila.","description":"Pain is a significant medical concern and represents a major unmet clinical need. The ability to perceive and react to tissue-damaging stimuli is essential in order to maintain bodily integrity in the face of environmental danger. To prevent damage the systems that detect noxious stimuli are therefore under strict evolutionary pressure. We developed a high-throughput behavioral method to identify genes contributing to thermal nociception in the fruit fly and have reported a large-scale screen that identified the Ca²⁺ channel straightjacket (stj) as a conserved regulator of thermal nociception. Here we present the minimal anatomical and neuronal requirements for Drosophila to avoid noxious heat in our novel behavioral paradigm. Bioinformatics analysis of our whole genome data set revealed 2","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011","modification":"2025-04-04T23:41:40.53Z","creation":"2019-03-26T23:07:43Z"},"accession":"S-EPMC3164203","cross_references":{"pubmed":["21909389"],"doi":["10.1371/journal.pone.0024343"]}}