{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee J"],"funding":["NCI NIH HHS"],"pagination":["502-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3164285"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["Total synthesis of (+)-isatisine A is described based on the application of a silyl-directed Mukaiyama-type [3 + 2]-annulation for the preparation of a fully substituted furan core. The indole branch forming the quaternary carbon center at C2 was constructed by addition to an intermediate N-acyliminium ion derived from aminal 4. In addition, the fused tetracyclic framework including furan core was built up using modified Buchwald amidation conditions."],"journal":["Organic letters"],"pubmed_title":["Total synthesis of (+)-isatisine A."],"pmcid":["PMC3164285"],"funding_grant_id":["R01 CA056304-13","CA 53604"],"pubmed_authors":["Lee J","Panek JS"],"additional_accession":[]},"is_claimable":false,"name":"Total synthesis of (+)-isatisine A.","description":"Total synthesis of (+)-isatisine A is described based on the application of a silyl-directed Mukaiyama-type [3 + 2]-annulation for the preparation of a fully substituted furan core. The indole branch forming the quaternary carbon center at C2 was constructed by addition to an intermediate N-acyliminium ion derived from aminal 4. In addition, the fused tetracyclic framework including furan core was built up using modified Buchwald amidation conditions.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Feb","modification":"2025-04-04T23:41:10.374Z","creation":"2019-03-27T00:43:28Z"},"accession":"S-EPMC3164285","cross_references":{"pubmed":["21188973"],"doi":["10.1021/ol102848w"]}}