biostudies-literatureLee JNCI NIH HHS502-5https://www.ebi.ac.uk/biostudies/studies/S-EPMC3164285biostudies-literatureUnknown13(3)Total synthesis of (+)-isatisine A is described based on the application of a silyl-directed Mukaiyama-type [3 + 2]-annulation for the preparation of a fully substituted furan core. The indole branch forming the quaternary carbon center at C2 was constructed by addition to an intermediate N-acyliminium ion derived from aminal 4. In addition, the fused tetracyclic framework including furan core was built up using modified Buchwald amidation conditions.Organic lettersTotal synthesis of (+)-isatisine A.PMC3164285R01 CA056304-13CA 53604Lee JPanek JSfalseTotal synthesis of (+)-isatisine A.Total synthesis of (+)-isatisine A is described based on the application of a silyl-directed Mukaiyama-type [3 + 2]-annulation for the preparation of a fully substituted furan core. The indole branch forming the quaternary carbon center at C2 was constructed by addition to an intermediate N-acyliminium ion derived from aminal 4. In addition, the fused tetracyclic framework including furan core was built up using modified Buchwald amidation conditions.2011-01-01T00:00:00Z2011 Feb2025-04-04T23:41:10.374Z2019-03-27T00:43:28ZS-EPMC31642852118897310.1021/ol102848w