{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Colonne PM"],"funding":["NIAID NIH HHS"],"pagination":["3733-43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3165482"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(9)"],"pubmed_abstract":["Infection of the endothelial cell lining of blood vessels with Rickettsia conorii, the causative agent of Mediterranean spotted fever, results in endothelial activation. We investigated the effects of R. conorii infection on the status of the Janus kinase (JAK)-signal transducer and activator of transcription protein (STAT) signaling pathway in human microvascular endothelial cells (HMECs), the most relevant host cell type, in light of rickettsial tropism for microvascular endothelium in vivo. R. conorii infection induced phosphorylation of STAT1 on tyrosine 701 and serine 727 at 24, 48, and 72 h postinfection in HMECs. Employing transcription profile analysis and neutralizing antibodies, we further determined that beta interferon (IFN-β) production and secretion are critical for STAT1 act"],"journal":["Infection and immunity"],"pubmed_title":["Beta interferon-mediated activation of signal transducer and activator of transcription protein 1 interferes with Rickettsia conorii replication in human endothelial cells."],"pmcid":["PMC3165482"],"funding_grant_id":["AI067613","AI076697","R01 AI040689","R21 AI076697","AI040689","R21 AI040689","R01 AI067613"],"pubmed_authors":["Sahni SK","Eremeeva ME","Colonne PM"],"additional_accession":[]},"is_claimable":false,"name":"Beta interferon-mediated activation of signal transducer and activator of transcription protein 1 interferes with Rickettsia conorii replication in human endothelial cells.","description":"Infection of the endothelial cell lining of blood vessels with Rickettsia conorii, the causative agent of Mediterranean spotted fever, results in endothelial activation. We investigated the effects of R. conorii infection on the status of the Janus kinase (JAK)-signal transducer and activator of transcription protein (STAT) signaling pathway in human microvascular endothelial cells (HMECs), the most relevant host cell type, in light of rickettsial tropism for microvascular endothelium in vivo. R. conorii infection induced phosphorylation of STAT1 on tyrosine 701 and serine 727 at 24, 48, and 72 h postinfection in HMECs. Employing transcription profile analysis and neutralizing antibodies, we further determined that beta interferon (IFN-β) production and secretion are critical for STAT1 act","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Sep","modification":"2025-04-05T11:09:32.167Z","creation":"2020-11-19T13:27:36Z"},"accession":"S-EPMC3165482","cross_references":{"pubmed":["21690236"],"doi":["10.1128/iai.05008-11","10.1128/IAI.05008-11"]}}